That's what it means when it says you are getting a concentration of 250mg/ml on the vial.
When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. Specializes in LTC. Peak ampicillin serum levels ranging from 109 to 150 mcg/mL are attained after administration of 2000 mg of ampicillin plus 1000 mg sulbactam and 40 to 71 mcg/mL after administration of 1000 mg ampicillin plus 500 mg sulbactam. I feel like a complete idiot asking this question, but must admit that math was never my forte. Of 99 pediatric patients evaluable for clinical efficacy, 60 patients received a regimen containing intravenous ampicillin and sulbactam for injection, and 39 patients received a regimen containing intravenous cefuroxime. Order: Ampicillin, 7.5mg/kg qoh IV over 20 minutes Directions: Reconstitute medication with 2mL of 0.9% Normal Saline for IM, 150mL of 0.9% Normal Saline for IV Patient weighs 19lbs.
Consult the following table for recommended volumes to be added to obtain solutions containing 375 mg ampicillin and sulbactam for injection per mL (250 mg ampicillin/125 mg sulbactam per mL). I apologize for wasting your time.So, with the new 100 mg/ml dilution, do you think drawing up the 2.6 ml from one vial would be a viable option?
That means you have more than twice the necessary dose in the solution you mixed and you don't need to mix another.
It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. With the 1000mg vial reconstituted, I get roughly 2.3ml total. Concurrent use of probenecid with ampicillin and sulbactam for injection may result in increased and prolonged blood levels of ampicillin and sulbactam. 365 0 obj
Top Answer. The corresponding mean peak serum levels for sulbactam range from 48 to 88 mcg/mL and 21 to 40 mcg/mL, respectively. dose is 110mg. Reconstituted solution should be diluted further in 0.9% sodium chloride (normal saline) to yield a concentration between 3 and 45 mg/mL (ampicillin sodium 2 to 30 mg/mL and sulbactam sodium 1 to 15 mg/mL). In patients treated with ampicillin and sulbactam for injection the possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. The following adverse reactions have been reported in clinical trials.The most frequently reported adverse reactions were diarrhea in 3% of the patients and rash in less than 2% of the patients.Additional systemic reactions reported in less than 1% of the patients were: itching, nausea, vomiting, candidiasis, fatigue, malaise, headache, chest pain, flatulence, abdominal distension, glossitis, urine retention, dysuria, edema, facial swelling, erythema, chills, tightness in throat, substernal pain, epistaxis and mucosal bleeding.Available safety data for pediatric patients treated with ampicillin and sulbactam for injection demonstrate a similar adverse events profile to those observed in adult patients.
Solutions should be allowed to stand after dissolution to allow any foaming to dissipate in order to permit visual inspection for complete solubilization.1.5 gram and 3 gram vials: ampicillin and sulbactam sterile powder may be reconstituted directly to the desired concentrations using any of the following parenteral diluents.
These reactions are more apt to occur in individuals with a history of penicillin hypersensitivity and/or hypersensitivity reactions to multiple allergens.
If she is correct then we are calculating all our doses incorrectly because we are not taking into account the extra 0.1 ml. However, it is not known whether the use of ampicillin and sulbactam for injection in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary.Low concentrations of ampicillin and sulbactam are excreted in the milk; therefore, caution should be exercised when ampicillin and sulbactam for injection is administered to a nursing woman.The safety and effectiveness of ampicillin and sulbactam for injection have been established for pediatric patients one year of age and older for skin and skin structure infections as approved in adults. Hepatic toxicity is usually reversible; however, deaths have been reported.
The 250 mg vial of Ampicillin says to add 2.5 ml preservative free sterile water and this will make a dilution of 250 mg/ml.I suppose because of the powder in the vial, when we add 2.5 ml sterile water, it actually makes 2.6 ml in the vial.I believe that if I am able to draw up 2.6 ml from this vial then I have 260 mg in the syringe.
It's that old "dose ordered divided by the concentration available= amount to be given " calculation. I'm thinking that if the med in the vial is 250mg ,its 250mg regardless of how many mls the mixed volumn is. Answer: The procedures for reconstituting medications is highly scrutinized by the Food and Drug Administration (FDA). allnurses is Registered ® Copyright © allnurses.com
The pH of the solutions is between 8.0 and 10.0.Dilute solutions (up to 30 mg ampicillin and 15 mg sulbactam per mL) are essentially colorless to pale yellow. (Ampicillin is, however, degraded by beta-lactamases and therefore the spectrum of activity does not normally include organisms which produce these enzymes. Call the doc and ask him if he really wanted 260mg!! I'm thinking about Rocephin, once mixed its 2.1mls that is given to get the total mg dosage.
Specializes in NICU.