© 2020 American College of Clinical Pharmacology In study 2, population pharmacokinetic modeling was employed to build covariate-structured models using an independent data set of linezolid concentrations obtained during routine therapeutic drug monitoring (TDM). Unable to load your delegates due to an error 2020 Apr 21;64(5):e00027-20.

© The Author(s) 2019. However, platelet counts and hemoglobin levels were shown to be significantly lower in such patients than in patients with normal renal function. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcGF4aWwtYnJpc2RlbGxlLXBhcm94ZXRpbmUtMzQyOTU5 • Reappraisal of Linezolid Dosing in Renal Impairment To Improve Safety ANTIMICROBIAL AGENTS AND CHEMOTHERAPY https://bit.ly/2oTB9ny • Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-β-Lactamase ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Please enable it to take advantage of the complete set of features! 2018 Aug;57(8):989-1000. doi: 10.1007/s40262-017-0606-5.Jones SJ, Nichols KR, DeYoung HL, Cox EG, Knoderer CA.J Pediatric Infect Dis Soc. Ryan L Crass, Pier Giorgio Cojutti, Manjunath P Pai, Federico Pea Antimicrobial Agents and Chemotherapy 2019, 63 (8) Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis. doi: 10.1093/ofid/ofaa090. USD $35.00 Don't already have an Oxford Academic account? Doses greater than 30 mg/day have not been studied; should not exceed 40 mg/day. All rights reserved. Thrombocytopenia occurred overall in 14.8% of cases (9/61). © 2020 American College of Clinical Pharmacology Worryingly, in a recent retrospective analysis of 10 years of activity of linezolid TDM carried out at our centre we showed that 33.0% of 1049 patients receiving the fixed 600 mg every 12 h standard dose had a C min above this threshold.

Patients with renal impairment are at increased risk for thrombocytopenia and may benefit from lower doses, whereas some patients with clearance >90 mL/minute may need every 8-hour dosing to ensure efficacy, particularly when receiving treatment for early stages of serious high-inoculum infections. This article is also available for rental through DeepDyve.

Clin Pharmacokinet. Estimating Renal Function in Drug Development: Time to Take the Fork in the Road. Stress Incontinence (Off-label) 2.5-5 mg PO q8-12hr. Linezolid (Zyvox), belonging to oxazolidinone antibiotics, is commonly used for the treatment of patients infected with methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant enterococci.Although linezolid has been approved worldwide, the Japanese pharmacokinetic (PK) profile has not been characterized in detail. {Summary and comment in New Engl J Med Journal Watch Infectious Diseases 8/21/19} Impact Factor: 4.256 Crass, R.L. 2013;59(5):319-24. doi: 10.1159/000356756. You could not be signed in. Copyright © 2019 American Society for Microbiology. 2015 Sep;4(3):272-5. doi: 10.1093/jpids/piu035. Search for other works by this author on: Time-to-event analyses were performed using Cox proportional-hazards models.