Social Disadvantage, Politics, and SARS-CoV-2 Trends: A County-Level Analysis of United States Data It is used for the treatment of infections caused by drug-resistant, gram-positive organisms, including methicillin-resistant The package insert for linezolid contains the following wording regarding the potential for drug-drug interactions with other serotonergic agents: “Co-administration of linezolid and serotonergic agents was not associated with serotonin syndrome in Phase 1, 2 or 3 studies.
In addition, patients who were sedated and in an intensive care unit may not have demonstrated recognizable signs and symptoms of serotonin syndrome.In our study, only 2 patients with high probability of serotonin syndrome were identified among 52 patients (4%) receiving concomitant therapy with venlafaxine or an SSRI, and no patients with high probability were identified among those receiving therapy with linezolid and an SSRI plus venlafaxine within 14 days after hospitalization. Seven patients did not receive both types of therapy within a 14-day period and were excluded from the study. The Sternbach criteria and Boyer algorithm for diagnosis of serotonin syndrome were used to identify clinical features of serotonin syndrome. Three of the Sternbach clinical criteria were met, including mental status changes, agitation, and fever, but none of the Boyer criteria were met. Caution and close monitoring are recommended when prescribing this agent to these patients.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The serotonergic properties of linezolid inhibit serotonin metabolism, and SSRIs and venlafaxine prevent reuptake of serotonin into the presynaptic neuron. Another limitation to the study includes concurrent medications that could mask, mimic, or enhance the signs and symptoms of serotonin syndrome. Thank you for submitting a comment on this article. This may have increased the risk for the signs and symptoms of serotonin syndrome.
It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription. The potential for drug-drug interactions with linezolid and the antioxidants Vitamin C and Vitamin E was studied in healthy volunteers. Spontaneous reports of serotonin syndrome associated with co-administration of ZYVOX and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors (SSRIs), have been reported” [Review of cases of linezolid and serotonergic interactions with selective serotonin reuptake inhibitors (SSRIs) or venlafaxine that potentially resulted in serotonin syndrome.Review of cases of linezolid and serotonergic interactions with selective serotonin reuptake inhibitors (SSRIs) or venlafaxine that potentially resulted in serotonin syndrome.In addition, although it is not explicitly contraindicated, Micromedex strongly cautions against concurrent use of linezolid and SSRIs: “Concurrent use of linezolid and citalopram should be approached with caution. Please check with a physician if you have health questions or concerns. Baltimore, Maryland Linezolid (Zyvox; Pfizer), the first antibiotic in the oxazolidinone class, received approval from the US Food and Drug Administration in April 2000.
However, the signs and symptoms of serotonin syndrome did not progress, even with continued therapy, making the diagnosis of serotonin syndrome unlikely.
Time-kill curve studies. Sixty-five of the 72 patients in this study received a serotonergic medication other than linezolid or an SSRI. Select one or more newsletters to continue. Foods that are high in tyramine include, but are not limited to, air dried meats; aged or fermented meats; sausage or salami; pickled herring; anchovies; liver; red wine; beer; aged cheeses, including blue, brick, brie, cheddar, parmesan, romano, and swiss; sour cream; sauerkraut; canned figs; raisins; bananas or avocados (particularly if overripe); soy beans; soy sauce; tofu; miso soup; bean curd; fava beans; or yeast extracts (such as Marmite). Both patients were receiving at least 1 other serotonergic agent, which may increase the potential for signs and symptoms of serotonin syndrome.Limitations of this study include its retrospective nature.