Responses (1) MA. Fenofibrate is a peroxisome proliferator receptor alpha activator approved in 2008 for concurrent administration with a statin to improve the lipid profile. For a complete list of all side effects, Medicines that interact with fenofibrate may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with fenofibrate. Significant elevation of triglycerides, greater than 400, can cause inflammation of the pancreas, so people with very elevated triglyceride levels would benefit from a fibrate medication. Owing to the volume of mail, personal replies cannot be provided. Revision date: January 26, 2020.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. That's not to say fibrates aren't the right choice for some people, however. Asked 17 Apr 2017 by Daddyron8 Updated 17 April 2017 Topics fenofibrate, drug. So too might those with elevated triglycerides and normal LDL cholesterols.Before you suggest combining a statin and a fibrate for added benefit, be aware that the combination can increase the risk of muscle aches and possible muscle breakdown. They work by binding to the enzyme HMG-CoA reductase, which the liver needs to form cholesterol.Statins act in another way as well. Fenofibrate is more effective than statins at increasing HDL cholesterol levels, similar to atorvastatin and rosuvastatin at reducing triglyceride levels, but less effective than statins at lowering LDL cholesterol levels. Common medications that may interact with fenofibrate include:Alcohol may make fenofibrate treatment less effective.Note that this list is not all-inclusive and includes only common medications that may interact with fenofibrate. Is fenofibrate a "statin" drug? )http://www.uexpress.com/ask-the-doctors/2017/2/27/fibrates-may-be-better-option-than
It followed more than 4,000 middle-aged men with elevated triglyceride levels for five years. At the start of the study, one group began using gemfibrozil, and the other group began taking a placebo. Unlike statins, fibrates should be taken before eating.Statins have undeniably shown benefits in decreasing the risk of both heart attacks and strokes; fibrates seem to have a more narrow benefit. Because they make cholesterol levels fall within the liver, the liver then increases production of a substance, or receptor, that takes LDL, the so-called "bad" cholesterol, from the bloodstream and shepherds it back into the liver. There, it is eventually removed via the bile. Also in such cases, I try to lower the statin dose to decrease the chance of muscular symptoms.In summary, statins and fibrates work by different mechanisms. Answer this question. Gemfibrozil (Lopid) and fenofibrate (TriCor) appear equally safe and effective.
Fenofibrate is more convenient, since it is taken once rather than twice a day, but generic gemfibrozil is substantially less expensive.
Fibrates, though, may be appropriate for people with elevated triglyceride levels. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Statins, more officially known as HMG-CoA reductase inhibitors, target cholesterol in the bloodstream, most of which comes from the liver, not from foods that we eat.
Fenofibrate is effective at reducing triglyceride levels and increasing HDL cholesterol levels; however, it is less effective than statins at reducing LDL cholesterol levels. They work by decreasing the liver's release of triglycerides and by increasing the production of lipoprotein lipase, which breaks down triglycerides. "Fibric acid derivatives or fibrates are regarded as broad-spectrum lipid lowering drugs.
In addition, fibrates increase the formation of HDL, the so-called "good" cholesterol; they have only minor effects in reducing LDL. You should refer to the prescribing information for fenofibrate for a complete list of interactions.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use fenofibrate only for the indication prescribed.Copyright 1996-2020 Drugs.com. That's not to say fibrates aren't the right choice for some people, however. Statins are also known as HMG-CoA reductase inhibitors. Simvastatin is effective at lowering cholesterol; however, it may cause muscle pain particularly at higher dosages. No, it belongs to the drug class fibric acid derivatives.