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Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 Sci China Life Sci.

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Hydroxychloroquine is an antimalarial drug being tested as a potential treatment for the novel coronavirus disease 2019 (COVID‐19) pandemic caused by the severe acute respiratory syndrome coronavirus 2. 2020 May 15;1-7. doi: 10.1007 ... We sought to determine whether hydroxychloroquine (HCQ) application may reduce the death risk of critically ill COVID-19 patients. The purpose of this study is to evaluate whether hydroxychloroquine is effective in treatment of Hashimoto's thyroiditis. Although the efficacy of hydroxychloroquine for COVID‐19 remains uncertain, it may serve as a potential prophylactic agent especially in those at high risk, such as healthcare workers, household contacts of infected patients, and the immunocompromised. Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Surgery, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USADepartment of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota, USADepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USAUse the link below to share a full-text version of this article with your friends and colleagues.

I have read and accept the Wiley Online Library Terms and Conditions of UseDiscovering drugs to treat coronavirus disease 2019 (COVID‐19)Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS‐CoV‐2 infection in vitroIn vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)Towards optimization of hydroxychloroquine dosing in intensive care unit COVID‐19 patientsOptimizing hydroxychloroquine dosing for patients with COVID‐19: An integrative modeling approach for effective drug repurposingPharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by plasmodium vivaxSteady‐state pharmacokinetics of hydroxychloroquine in patients with cutaneous lupus erythematosusReport of the WHO‐China Joint Mission on Coronavirus Disease 2019 (COVID‐19)A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease‐19 (COVID‐19)Hydroxychloroquine and azithromycin as a treatment of COVID‐19: results of an open‐label non‐randomized clinical trialPlasma protein binding of the enantiomers of hydroxychloroquine and metabolitesSimultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC‐ESI‐MS/MS: an application for pharmacokinetic studiesHydroxychloroquine is much less active than chloroquine against chloroquine‐resistant Plasmodium falciparum, in agreement with its physicochemical propertiesTherapeutic status of hydroxychloroquine in COVID-19: A review, Chloroquine and hydroxychloroquine in the management of COVID-19: Much kerfuffle but little evidence, Recommendations for use of a hydroxychloroquine loading dose in patients with COVID-19, Cutaneous side effects of hydroxychloroquine in health care workers in a COVID referral hospital – implications for clinical practice, An Updated Systematic Review of the Therapeutic Role of Hydroxychloroquine in Coronavirus Disease-19 (COVID-19), A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19, Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infection, The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse, © 2020 American Society for Clinical Pharmacology and Therapeutics