If you can find rodent data for any of these drugs, I would be interested to pass it on.Unfortunately, all I’ve heard so far is anecdotal, pertaining more to Parkinson’s than to longevity, and thus not enough to act on. Now I just a 5 mg pill once or twice a week. I’m really hoping to see if it wil help me.It’s over a year since anyone posted in this thread.A quick pubmed search seems to show not much recent interest in selegiline. But why should it affect aging? Upping the dose to 2mg twice a week might produce elevated mood/energy for me, but that’s not my goal with taking Selegeline, also more does not always equal better.Taking deprenyl greatly increases the activity of superoxide dismutase (SOD) – an antioxidant naturally produced in our body. Type A breaks down all four of the MAO’s listed above. What happened to “Speed kills”? Veuillez réessayerMalheureusement, nous n'avons pas réussi à enregistrer votre vote. Typical doses used in the life extension community are 0.01 or 0.02 mg/kg, which are 20 to 50 times smaller than the dose that causes shortened life span in mice.0.5mg/kg for a mouse equates to 0.04mg/kg for a human, or 2.8mg for a 70kg human, very close to your dose of 2.5mg. It was surmised that Deprenyl could be used for its anti-depressant properties. Do you think this is a possibly fruitful stratagem for life-extension?I recently had an 8 hour I.V. I also find myself more alert and my reaction time is much better. The electrical network of the brain is modulated chemically by neurotransmitters that determine how easily and strongly its signals are transduced. It helps.To put this in context, there is lots of room between 0.5mg/kg and usual doses of Selegiline in humans. DLB is sort of the complement of Parkinson’s disease. The last 20 years I have also ate for health, avoiding junk, sugar and going organic. What did you think about it afterwards?Hi ginger; I have been interested in trying NAD+. Pour calculer l'évaluation globale en nombre d'étoiles et la répartition en pourcentage par étoile, nous n'utilisons pas une moyenne simple. After being sold for years as an anti-aging supplement and a treatment for Parkinson's disease, the … “Back of the envelope” figuring and Joseph Knolls’ findings suggest that ~1mg. It is sold as Selegiline (or Emsam transdermal). Deprenyl liquid can be titrated precisely for antiaging purposes, as each ml drop in the bottle is equivalent to 1mg deprenyl citrate and regular doses are considered to be 1mg to 3mg daily. I lived an abusive life style drinking 35 years an average of 16 oz. It may be because typical dosages of deprenyl are small compared to recreational dosages of meth.Why the difference in results? The book recounts how it was developed, the people that developed it and popularised it, the amazing benefits it provides to sufferers of Alzheimer's and Parkinson's disease, its preventive action against these, and its by now unquestioned role in extending lifespan. No complaints about the seller. by Ward Dean, M.D., and Steven Wm. This MAO-B inhibiting mechanism has been shown to support mental acuity and longevity.1In a double-blind, randomized, placebo-controlled trial in aging volunteers with below-average cognition, researchers demonstrated that 1,600 mg of the same wild green oat extract found in Dopa-Mind™ produced a 74% improvement on a standard test of mental acuity.1In soon-to-be published research, 800 mg of the same extract supported mental processing time and speed.2 In other research, this extract exhibited support for cerebral vasodilator function, as well as endothelial function — both of which play roles in brain health.3Breakthrough supplement for memory, cognition, and moreThe wild green oat extract in Dopa-Mind™ has been shown to promote more youthful cognitive performance in those where it is showing signs of waning, help maintain cognitive function in those whose minds are still healthy, and may support longevity.The suggested dose is one tablet of Dopa-Mind™ daily for the first month. It is often very hard to translate mouse dose into human dose because they have different metabolism and drug detoxification rates than humans (even absorption is different). Deprenyl: The Anti-Aging Drug. However, the mouse studies that I’ve seen were with injected deprenyl (not oral). sc daily would deliver deprenyls’ benefits with no possible MAO complications. Dopamine, adrenaline, melatonin and serotonin are all common examples of mono-amine neurotransmitters, named for a chemical structure they have in common. LOLI started out with the liquid form of a citrate which can’t be found now. La commande 1-Click n'est pas disponible pour cet article. Neurotransmitters are constantly being produced in response to stimuli, and broken down so their levels in the brain can be adjusted from moment to moment. At that time, MAO Inhibitors were the subject of research for their mood-altering effects. 51 thoughts on “ Deprenyl: understudied, little-known anti-aging drug ” B on September 12, 2013 at 3:41 pm said: The reason the presumed effects of the metabolite methamphetamine aren’t noticed is that the active drug form of meth is D-methamphetamine, selegline/deprenyl metabolizes into L-methamp which doesn’t give the same euphoric effects. Very informative and also helps explain why so many useful things never make it through the FDA. I am 41 yr old female 112 lbs. If desired results do not manifest, increase the dose to two tablets daily.Help promote and maintain youthful cognitive performance and longevity. This is why our endogenous and exogenous antioxidant systems must be kept in balance. Only 5 left in stock - order soon. Impossible d'ajouter l'article à votre liste. Deprenyl: A Universal Anti-Aging Strategy? A bad reaction is suggestive of DLB.I’m wondering if Deprenyl really is helpful in DLB.