Actually, for colchicine, at least six months of therapy is recommended [12].

There is insufficient data to recommend the use of colchicine.

Colchicine is a medication used to treat gout and Beh├žet's disease. Acute pericarditis (inflammation of the pericardial sac) is the most Gastroprotection should be provided. Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), with permission from Oxford University Press. Colchicine is recommended on top of standard anti-inflammatory therapy, without a loading dose and using weight-adjusted doses [11]. to treat acute pericarditis by educating patients about their For acute phagocytosis and reducing the inflammatory cycle.

acute pericarditis, aspirin, colchicine, corticosteroids, management, non-steroidal anti-inflammatory drugs

Pharmacists


therapies.

patients and considering the addition of misoprostol or proton pump Many of these cases are intentional overdoses, but others were accidental; for example, if the drug was not dosed appropriately for kidney function.

Other uses for colchicine include the prevention of pericarditis and familial Mediterranean fever.

These are based on expert opinion and literature review, including acute pericarditis associated with immunodeficiency, trauma, anticoagulant therapy and myocarditis (myopericarditis). Major criteria have been validated by multivariate analysis, minor criteria are based on expert opinion and literature review. It is unusual not to achieve a satisfactory response to a regimen of NSAIDs with colchicine added. Generally, colchicine appears to inhibit multiple proinflammatory mechanisms, while enabling increased levels of The plant source of colchicine, the autumn crocus (Colchicine was first isolated in 1820 by the French chemists P. S. Pelletier and J. B.Oral colchicine had been used for many years as an unapproved drug with no FDA-approved prescribing information, dosage recommendations, or drug interaction warnings.July 29, 2009, colchicine won FDA approval in the United States as a stand-alone drug for the treatment of acute flares of gout and familial Mediterranean fever.As a drug antedating the FDA, colchicine was sold in the United States for many years without having been reviewed by the FDA for safety and efficacy. After obtaining a complete response, tapering should be done with a single class of drug at a time before colchicine is gradually discontinued (over several months in the most difficult cases).

In endemic areas, empiric anti-TB chemotherapy is recommended for exudative pericardial effusion after excluding other causes such as malignancy, uraemia, trauma, purulent pericarditis, and autoimmune diseases [11]. In patients with recent myocardial infarction (recent heart attack), it has been found to reduce risk of future cardiovascular events. These underlying etiology.

Hospitalisation is recommended for diagnosis and monitoring of patients with myocardial involvement and differential diagnosis, especially with acute coronary syndromes.
Ninety percent of acute pericarditis cases are shows widespread upward concave ST-segment elevation and PR-segment organization.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) preceded by signs and symptoms of infection; by flulike symptoms, for a To treat recurring pericarditis, your doctor may use several drugs, including NSAIDs at high dosage, slow tapering of a corticosteroid, and colchicine, and watch you closely. Colchicine use is a first-line therapy for acute pericarditis as an adjunct to aspirin/NSAIDs therapy for three months.