0000084325 00000 n In particular that treatment delays of more than 48 hours required dose re-titration of clozapine, usually over a 14 day period as an in-patient. • Recommence at 12.5mg once or twice daily on the first day.

Q: 38-year-old patient with history of treatment-resistant schizophrenia was stable on clozapine 350 mg bedtime dosing. endobj T��$I�&Q�R�C)�"�zc� If clozapine is missed for greater than 48 hours, the dose must be re-titrated and monitoring must return to a weekly cycle15. 0000205983 00000 n

You should take your missed dose of clozapine as soon as you remember. Dosing recommendations if clozapine dose is missed for greater than 48 hours • Obtain psychiatric review prior to recommencing clozapine.

0000186875 00000 n 0000007416 00000 n <> < Do not double dose. If it has been more than two days, contact your doctor. 0000026835 00000 n 0000014647 00000 n If it is already close to the time of your next scheduled dose, skip the missed dose and continue with your next dose as usual. 0000012374 00000 n Serious adverse effects including tachycardia, postural hypotension, myocarditis and seizure activity can occur if a full treatment dose is administered after a break in treatment. •If 2 or more days of clozapine doses are missed, restarted with one half of a 25mg tablet (12.5 mg) once or twice daily. Do not double dose.Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view.

This has a negative impact on the patient and can prove to be a preventable burden to NHS resources. Clozapine is prescribed to relieve the symptoms of psychosis. •If 2 or more days of clozapine doses are missed, restarted with one half of a 25mg tablet (12.5 mg) once or twice daily. 0000076162 00000 n You may need to restart the medication at a lower dosage.

s 0000053217 00000 n 0000023859 00000 n 0000008327 00000 n %PDF-1.5 0000034169 00000 n 0000206419 00000 n Restarting Clozapine After Missed Dose. 3 0 obj <>>> The Food and Drug Administ 0000008588 00000 n 5 0 obj

0000181645 00000 n 4 0 obj -Concomitant use of clozapine is not recommended, however, if a strong CYP450 3A4 inducer is necessary, a dose increase of clozapine dose may be needed.

0000009268 00000 n Monitor for decreased effectiveness.-When discontinuing a strong CYP450 3A4 inducer and continuing clozapine: Reduce clozapine dose based on clinical response. 0000116589 00000 n Given the pharmacokinetics of clozapine, differences of a few hours in the time of evening dosing and/or morning plasma sampling will lead to large differences in reported plasma levels. 0000145233 00000 n :Xk����p��ǵ�{���k�A\��w^���"{���{�o��} S�� �jT�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I�$I��WO}֐�Z�/��d�/j��y����. 0000027003 00000 n 0000075648 00000 n 0000084065 00000 n If it is already close to the time of your next scheduled dose, skip the missed dose and continue with your next dose as usual. 0000004863 00000 n

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