Several drugs have been withdrawn from the U.S. market or have received black box warnings due to their potential to cause QT interval prolongation that leads to fatal ventricular arrhythmias and sudden cardiac death. QT-interval prolongation is estimated to occur in up to 10% of patients taking antiarrhythmic drugs with QT-prolonging potential.The QT interval represents the summation of cardiac action potentials.Nonpsychiatric drugs that are well known for causing QTc prolongation, such as sotalol and dofetilide, extend the QTc interval by 30 to 40 ms.The majority of patients who develop drug-induced QT prolongation also have multiple risk factors (The antidepressants and antipsychotics that are correlated with a higher risk of QT prolongation are listed in Loxapine is not associated with QTc prolongation, according to a double-blind, placebo-controlled, crossover study in healthy volunteers.Quetiapine has had several mixed reports regarding its ability to prolong the QTc interval. Many medicines have not been tested for this risk in patients, especially those with congenital long QT syndrome. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. Associations are based on the strength of evidence that supports whether QT prolongation can occur. €€€€List last revised: May 12, 2020 Read More On: Unfortunately, many psychiatric medications such as antidepressants and antipsychotics have a risk of prolonging QT. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. This is usually worse for patients with Long QT Syndrome or for people taking anti arrhythmic drugs or other drugs also on the QT Drug list. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This effect is thought to occur when specific drugs interfere with cardiac potassium channels and repolarization. Unfortunately, many psychiatric medications such as antidepressants and antipsychotics have a risk of prolonging QT. Copyright © 2000 - 2020 Jobson Medical Information LLC unless otherwise noted. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. By using this Site you agree to the following It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. UPDATED JAN 2016 QT prolonging drugs lists can fit these three criteria: Possible Risk of QT prolongation/TdP Substantial evidence supports the conclusion that these drugs can cause QT prolongation BUT there is insufficient evidence at this time that these drugs, when used as directed in official labeling, are associated with a risk of causing TdP. Copyright © Vitals Consumer Services LLC Renal failure, cardiac failure and hepatic failure are also risk factors. Copyright © Vitals Consumer Services LLC We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Prolongation of the QT interval is a concern for clinicians managing psychiatric drug regimens.