The sodium (Na +) Each mL contains 2 mg of linezolid. 0000006498 00000 n %PDF-1.5 %���� 0000004719 00000 n Inactive ingredients are sodium citrate, citric acid, and dextrose in an aqueous vehicle for intravenous administration. A borate buffer (pH 8.0) containing sodium dodecyl sulfate was used as a run buffer and detection of linezolid was performed at 250 nm (its absorption maximum).

ZYVOX I.V. It is used in the treatment of bacterial infections such as pneumonia, skin infections or blood infections. %%EOF 0000000979 00000 n 0000012517 00000 n

Call your doctor for medical advice about side effects. 0000011236 00000 n

0000010037 00000 n

Bradycardia may be worsened when MAO-inhibitors are co-administered to patients receiving beta-blockers. d�c@ >�� &�$I�e2;��>�:���K���w���׉�W����/Sz�G��s"�}��3�2�)��LZ��/gpHhǁ��6� 0000005460 00000 n Zyvox solution for infusion, film-coated tablets or oral suspension may be used as initial therapy. 1; The words salt and sodium are not exactly the same, yet these words are often used interchangeably. 1; Ninety percent of the sodium we consume is in the form of salt. In Phase 3 comparator-controlled trials, the percentage of adult patients who developed a substantially low Changes seen in other laboratory parameters, without regard to drug relationship, revealed no substantial differences between ZYVOX and the comparators. Molten sodium is an excellent heat-transfer fluid, and, because of this property, it has found use as coolant in liquid-metal fast breeder reactors. This is not a complete list of side effects and others may occur. 0000015106 00000 n Bowel regularity means a bowel movement every day. 2.5 Constitution of Oral Suspension ZYVOX for Oral Suspension is supplied as a …

0000002231 00000 n Use linezolid cautiously in patients receiving beta-blockers. 0000003380 00000 n Sodium chloride is the chemical name for salt. Use linezolid cautiously in patients receiving beta-blockers. Call your doctor for medical advice about side effects. Uses. Zyvox (linezolid) is available in an IV form (strength is 2mg per ml), in tablets (strengths of 400 and 600mg) and in an oral suspension (strength is 100mg per 5ml). 3124 0 obj <>stream 0000005688 00000 n startxref 0000006179 00000 n x�b```b``�a`e`� These patients were enrolled in two Phase 3 comparator-controlled clinical trials and were treated for up to 28 days. 0000004957 00000 n Antibiotics such as linezolid injection will not kill … It works by stopping the growth of bacteria. Injection is supplied as a ready-to-use sterile isotonic solution for intravenous infusion. incompatibility resulted when ZYVOX I.V. Zyvox is an antibiotic (an agent used to destroy certain types of bacteria).

0000006258 00000 n Dose depends on the form of the drug used, the type of infection and if the drug is used to treat children or adults; the treating doctor should determine the dose. trailer The most common reported drug-related adverse events leading to discontinuation of treatment were nausea, headache, diarrhea, and vomiting.The safety of ZYVOX formulations was evaluated in 215 pediatric patients ranging in age from birth through 11 years, and in 248 pediatric patients aged 5 through 17 years (146 of these 248 were age 5 through 11 and 102 were age 12 to 17). Linezolid injection is used to treat infections, including pneumonia, and infections of the skin. 0000009170 00000 n For all other indications, discontinuations due to drug-related adverse events occurred in 2.1% of ZYVOX-treated and 1.7% of comparator-treated patients. 0000002346 00000 n Sodium is used extensively in metallurgy as a deoxidant and as a reducing agent for the preparation of calcium, zirconium, titanium, and other transition metals. �3�;�H��dQ`�qo�3&�r��)~ 0000008532 00000 n Cautions: Do not add supplementary medication or additives. 0000013739 00000 n Fungal Skin Infections: Types, Symptoms, and TreatmentsBowel regularity means a bowel movement every day. Injection was combined with ceftriaxone sodium. In the study of hospitalized pediatric patients (birth through 11 years) with Of the pediatric patients treated for uSSSIs, 19.2% of ZYVOX-treated and 14.1% of comparator-treated patients experienced at least one drug-related adverse event.

For all other indications, discontinuations due to drug-related adverse events occurred in 0.9% of ZYVOX-treated and 6.1% of comparator-treated patients.ZYVOX has been associated with thrombocytopenia when used in doses up to and including 600 mg every 12 hours for up to 28 days.

0000015325 00000 n 0000003834 00000 n For all other indications, 20.4% of ZYVOX -treated and 14.3% of comparator-treated patients experienced at least one drug-related adverse event.Table 2 shows the incidence of all-causality, treatment-emergent adverse reactions reported in at least 1% of adult patients in these trials by dose of ZYVOX.Of the patients treated for uSSSIs, 3.5% of ZYVOX-treated and 2.4% of comparator-treated patients discontinued treatment due to drug-related adverse events.