It is not recommended as first-line therapy, especially in the first trimester of pregnancy. Researchers granted that there could have been other confounding factors that affected the results, such as the fact that women with nausea and vomiting during pregnancy are generally less likely to have a spontaneous abortion. (n.d.). All Rights Reserved. Here’s why. We are so thankful that everything is continuing to go well and we are moving full-steam ahead preparing for our new arrivals! With the help of the Center for Disease Control and Prevention (CDC), the Slone Epidemiology Center at Boston University conducted a on whether ondansetron affects the likelihood of a baby having birth defects (3). A 2013 cohort study done in Denmark and published in The New England Journal of Medicine also found that use of Zofran in pregnancy (not just in the first trimester, though the majority of women who use the drug take it during the first trimester) was not associated with an increased risk of preterm delivery, low birth weight infants, small for gestational age infants, … Reglan and zofran are both in pregnancy drug class b. Canadian family physician Medecin de famille canadienTaking Ondansetron During Pregnancy Does Not Appear to Increase Risk For Birth Defects | CDC. It is also used to treat nausea and vomiting of pregnancy (NVP, otherwise known as “morning sickness”).Morning sickness is very common; seven in ten women reported experiencing it during the first three months of pregnancy (2). Because of these potential hazards, it is recommended that Zofran only be used after other methods of combating nausea and vomiting have been tried. You … But this proved to be the most dangerous time for pregnant patients to take Zofran, as the first trimester is a crucial developmental stage for the fetus. Yet many doctors still frequently prescribe it. In addition, its extreme form, hyperemesis gravidarum, affects less than 3% of pregnancies.Since then, the escalating use of ondansetron in the United States has been described using a large dataset covering 2.3 million, predominantly commercially insured, pregnancies that resulted in live births from 2001 to 2015.There have been two studies that have suggested an increased risk in specific major birth defects with first-trimester ondansetron use. The only drug in A is Diclegis, which is b6 and unisom. They say that further studies are necessary to get a full read on the effects of the drug.The FDA issued a warning in September 2011 about possible associations between Zofran and certain maternal heart issues, including QT prolongation and torsade de pointes. Once nausea and vomiting of pregnancy progresses, it can become more difficult to control symptoms. Answer this question. 1 Over that period of time, any outpatient pharmacy dispensing of an antiemetic in pregnancy increased from 17.0% in 2001 to 27.2% in 2014. Even worse, since morning sickness is most common during the first trimester of pregnancy, women taking Zofran do so during an infant’s most crucial development period. 13 Ondansetron commonly causes constipation, which may already be a problem in pregnancy. Second Trimester; Third Trimester; Book; Contact; 0; First Trimester Pregnancy Solutions. However, there were “modest increases” in risk of cleft palate and renal agenesis-dysgenesis associated with Zofran use in the first trimester (3).A 2013 cohort study done in Denmark and published in also found that use of Zofran in pregnancy (not just in the first trimester, though the majority of women who use the drug take it during the first trimester) was not associated with an increased risk of , any major birth defects, stillbirth, or spontaneous abortion (4). Millennial moms are just saying no to Zofran when pregnant. Retrieved June 11, 2019, from https://www.nejm.org/doi/full/10.1056/NEJMoa1211035 : This vitamin has been shown to reduce nausea, though it must be taken only in small amounts. The HIE Help Center serves as an informational resource guide for families of children with hypoxic-ischemic encephalopathy (HIE). Temporary nerve damage can result from taking more than 100 mg of Vitamin B6 a day. Nausea and vomiting of pregnancy (NVP) affects up to 80% of pregnant women, most commonly between 5 and 18 weeks of gestation. Is ondansetron safe for use during pregnancy?. The first, published in 2012, used data from the National Birth Defects Prevention case control study from 1997 to 2004 to examine risks with NVP and its treatments for the most common noncardiac defects in the dataset. The above information should not be taken as medical advice. The risks from zofran are very very minimal. Zofran can be prescribed as a tablet or in liquid form, and is also available in its generic form named ondansetron.