Tinidazole should not be used in patients with hypersensitivity to metronidazole. this site will not function whilst javascript is disabled.The above percentage of manuscripts have been rejected in the last 12 months.Open access peer-reviewed scientific and medical journals.We offer real benefits to our authors, including fast-track processing of papers.Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly.The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees.Dove Medical Press is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC We comply with the HONcode standard for trustworthy health information - GRETCHEN L. JOHNSON, PharmD, BCPS, Shenandoah University Bernard J. Dunn, School of Pharmacy, Winchester, VirginiaTinidazole (Tindamax), a second-generation nitroimidazole, is an antiprotozoal and antibacterial agent similar to metronidazole (Flagyl). per dose 2 g) for 3 days. 50–60 mg/kg once daily (max. See also: Metronidazole for BV; Tinidazole for BV; Trichomoniasis. Wiesenfeld HC, We hypothesize that qualities of tinidazole such as its longer half-life and its seemingly superior side effect profile as compared to oral metronidazole will result in its being a more efficacious drug for the treatment of BV than the currently available options. Oral tinidazole has been used to treat bacterial vaginosis for over 25 years but in a number of different dosage regimens. In animal reproduction studies, oral administration of tinidazole to pregnant mice and rats during organogenesis at 6 and 3 times, respectively, the maximum recommended human dose (based on body surface area comparison) showed a slight increase in fetal mortality in rats at highest dose, with no other adverse fetal effects noted in either species Tinidazole is U.S. Food and Drug Administration pregnancy category C (metronidazole is category B).Adverse effects are similar to those with metronidazole, the most common of which are weakness and gastrointestinal adverse effects (e.g., metallic/bitter taste, nausea, dyspepsia, vomiting, anorexia).Tinidazole is as effective as metronidazole for the treatment of trichomoniasis, with both achieving high cure rates.The cost of tinidazole ranges from $18 to $31 for single-dose treatment of trichomoniasis. The dose is usually 50 milligrams (mg) per kilogram (kg) of body weight per day (up to 2 g per day) for 3 to 5 days. Although not currently licensed in the U.S., tinidazole is an antimicrobial related to metronidazole which has shown promise for the treatment of BV in European studies and is widely used worldwide for the treatment of trichomoniasis including infections which are resistant to metronidazole.

Berman SM. For the treatment of bacterial vaginosis, tinidazole costs $36 to $61 for the two-day regimen and $46 to $76 for the five-day regimen. Forna F, In order to provide our website visitors and registered users with a service tailored to their individual preferences we use cookies to analyse visitor traffic and personalise content. Tinidazole 500 mg single dose provides better long-term cure rates than metronidazole 500 mg twice daily for 5 days and is more effective in preventing bacterial vaginosis relapses 16. COVID-19 is an emerging, rapidly evolving situation. Sexually transmitted diseases treatment guidelines, 2006 [published correction appears in Livengood CH III, Sobel JD, However, the etiology of BV remains unknown and the current treatment regimens are inadequate in terms of initial cure and recurrence rates. et al. San Antonio, Tex. Interventions for treating trichomoniasis in women. You can learn about our use of cookies by reading our If you agree to our use of cookies and the contents of our Privacy Policy please click 'accept'.

2 g once daily for 2–3 days. To see the full article, log in or purchase access.Address correspondence to Gretchen L. Johnson, PharmD, BCPS, at Tindamax (tinidazole) [prescribing information].

Bacterial vaginosis (BV) is the most prevalent cause of symptomatic vaginal discharge in the U.S. and has been associated with complications including preterm delivery of infants, pelvic inflammatory disease (PID), urinary tract infections (UTI) and acquisition/transmission of sexually transmitted diseases (STDs) including human immunodeficiency virus (HIV). Indications and dose Anaerobic infections Quadruple therapy includes tinidazole in combination with clarithromycin, amoxicillin, and a proton pump inhibitor (PPI) for 10 to 14 days.

For bacterial vaginosis, the tinidazole dose is 2 g once daily for two days or 1 g once daily for five days, which is a less frequent and shorter regimen than metronidazole 500 mg twice daily for seven days. Comments: -Treatment with a luminal amebicide should follow this 3- … Gülmezoglu AM.