The systemic clearance of sotalol was significantly greater in the antenatal period (2.4 +/- 0.3 ml/min/kg) than in the post-natal phase (1.5 +/- 0.1 ml/min/kg).
Plasma samples were analysed for sotalol using a fluorometric method and the pharmacokinetic profiles investigated.
Logistic regression was used to compare the rates of adverse events among the study groups after adjustment for the duration of follow-up.The regimens were administered in a double-dummy manner.The study was conducted in an outpatient setting between April 1, 1998, and October 31, 2002; 28 sites participated initially and 8 discontinued participation early. Amiodarone was superior to sotalol (P<0.001) and to placebo (P<0.001), and sotalol was superior to placebo (P<0.001). In the presence of normal renal function, sotalol's class III effects only begin at doses of 80 mg bid and increase linearly thereafter. Sotalol hydrochloride is a white, crystalline solid with a molecular weight of 308.8. Previously, smaller trials found amiodarone and sotalol to be effective as single agents in atrial fibrillation,An unexpected finding was that treatment with either sotalol or amiodarone resulted in similar times to a first recurrence of atrial fibrillation in patients with ischemic heart disease. Auch v… First, the animals received 0.5 mg prednisolone per kg body weight PO for 5 days (Day + 106 till Day + 110), which was followed by a washout period of 25 days.
Clipboard, Search History, and several other advanced features are temporarily unavailable. The total rate of conversion was 79.8 percent in the amiodarone group, as compared with 79.9 percent in the sotalol group (P=0.98) and 68.2 percent in the placebo group (P=0.01 for the comparison with both amiodarone and sotalol).
Please enable it to take advantage of the complete set of features! The sotalol regimen was 80 mg twice daily for the first week and 160 mg twice daily thereafter. koronare Herzkrankheiten ; arterielle Hypertonie; Herzrhythmusstörungen; 4 Allgemeines. The median times to a recurrence of atrial f ibrillation were 487 days in the amiodarone group, 74 days in the sotalol group, and 6 days in the placebo group according to intention to treat and 809, 209, and 13 days, respectively, according to treatment received. Unable to load your delegates due to an error Atrial fibrillation (AF) is the most common arrhythmia worldwide, affecting an estimated 33.5 million adults.Amiodarone and dofetilide are the only two AAD that are currently approved for restoration of SR in AF with concomitant CHF and left ventricular (LV) dysfunction (ejection fraction ≤35%).Amiodarone is the most effective AAD that is currently available for restoration and maintenance of SR in both paroxysmal and persistent AF.Amiodarone is an iodinated lipophilic compound with an unpredictable gastrointestinal absorption, and the bioavailability ranges widely from 22% to 86%.Amiodarone has been found to be more effective than sotalol, dronedarone, and propafenone in randomized controlled trials (RCTs).Dofetilide is another commonly used AAD that is approved by the US Food and Drug Administration (FDA) for the treatment of AF.Dofetilide has good oral bioavailability (90%), and the estimated half-life is approximately 10 hours.
); the Department of Veterans Affairs Medical Center, Washington, D.C. Bramah Singh reports having acted in an advisory capacity and as a speaker for Wyeth–Ayerst Laboratories, Sanofi-Synthelabo Laboratories, and Berlex Laboratories. Klicken und ziehen, um das 3D-Modell auf der Seite zu verschieben. Patients who initially converted to sinus rhythm but in whom atrial fibrillation recurred after day 28 received another dose of anticoagulants before again undergoing DC cardioversion; the study drug was withdrawn if atrial fibrillation recurred after the second attempt. It is often used in atrial fibrillation/flutter. 2015 Nov;39(7):532-6. doi: 10.1053/j.semperi.2015.08.007.
There was only one case of torsades de pointes in a patient in the sotalol group, and three of adverse pulmonary effects, two in the amiodarone group and one in the placebo group.