Management: Use of sildenafil for pulmonary hypertension should be avoided with strong CYP3A4 inhibitors.
Generic Levitra - a drug designed for men with a reduced erectile function and sexual impotence. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects).Dapoxetine: May enhance the orthostatic hypotensive effect of Phosphodiesterase 5 Inhibitors.Deferasirox: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).Duvelisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). I figure as long as she is happy with me that is all that matters .I'm 71 and used ED drugs now for 15 years. )Gastrointestinal: Dyspepsia (3% to 17%; dose-related)Ophthalmic: Visual disturbance (2% to 11%; including vision color changes, blurred vision, and photophobia; dose-related)Central nervous system: Insomnia (≤7%), dizziness (2% to 4%), paresthesia (≤3%)Gastrointestinal: Diarrhea (3% to 9%), gastritis (≤3%), nausea (2% to 3%)Neuromuscular & skeletal: Myalgia (2% to 7%), back pain (3% to 4%)Respiratory: Nasal congestion (4% to 9%), exacerbation of dyspnea (≤7%), nasal congestion (4%), rhinitis (4%), sinusitis (3%)<2%, postmarketing, and/or case reports (limited to important or life-threatening): Abdominal pain, abnormal dreams, abnormal hepatic function tests, absent reflexes, accidental injury, amnesia (transient global), anemia, angina pectoris, anorgasmia, anterior chamber eye hemorrhage, anterior ischemic optic neuropathy, anxiety, arthritis, asthma, ataxia, atrioventricular block, auditory impairment, basal cell carcinoma (Loeb 2015), bone pain, breast hypertrophy, bronchitis, burning sensation of eyes, cardiac arrest, cardiac failure, cardiomyopathy, cataract, cerebral hemorrhage, cerebral thrombosis, cerebrovascular hemorrhage, chest pain, chills, colitis, conjunctivitis, contact dermatitis, cystitis, depression, dermal ulcer, diaphoresis, diplopia, drowsiness, dry eye syndrome, dysphagia, ECG abnormality, edema, ejaculatory disorder, esophagitis, exfoliative dermatitis, eye pain, eye redness, facial edema, falling, gastroenteritis, genital edema, gingivitis, glossitis, gout, hearing loss, hematuria, hemorrhage, herpes simplex infection, hyperglycemia, hypernatremia, hypersensitivity reaction, hypertension, hypertonia, hyperuricemia, hypoesthesia, hypoglycemia, hypotension, increased bronchial secretions, increased cough, increased intraocular pressure, increased thirst, ischemic heart disease, leukopenia, laryngitis, malignant melanoma (Li 2014; Loeb 2015), migraine, myasthenia, mydriasis, myocardial infarction, neuralgia, neuropathy, nocturia, orthostatic hypotension, ostealgia, osteoarthritis, otalgia, pain, palpitations, peripheral edema, pharyngitis, photophobia, priapism, prolonged erection, pruritus, pulmonary hemorrhage, rectal hemorrhage, retinal edema, retinal hemorrhage, retinal vascular disease, rupture of tendon, seizure, severe sickle cell crisis (vaso-occlusive crisis in patients with pulmonary hypertension associated with sickle cell disease), shock, skin photosensitivity, stomatitis, subarachnoid hemorrhage, swelling of eye, syncope, synovitis, tachycardia, temporary vision loss, tenosynovitis, tinnitus, transient ischemic attacks, tremor, unstable diabetes, urinary frequency, urinary incontinence, urticaria, ventricular arrhythmia, vertigo, visual field loss, vitreous detachment, vitreous traction, vomiting, weakness, xerostomia• Color discrimination: May cause dose-related impairment of color discrimination. In another retrospective report (n=45, median age: 32.6 months; range: 6 days to 17 years), a mean dose of 0.9 ± 0.3 mg/kg/dose four times daily was reported (Uhm, 2010). It is really tough for a man that looks for improving his overall health condition. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation and inflow of blood to the corpus cavernosum.
To understand how they … Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane.Molsidomine: May enhance the hypotensive effect of Phosphodiesterase 5 Inhibitors.Netupitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Nitroprusside: Phosphodiesterase 5 Inhibitors may enhance the hypotensive effect of Nitroprusside.
Consult appropriate manufacturer labeling.CYP3A4 Inhibitors (Moderate): May increase the serum concentration of Sildenafil.CYP3A4 Inhibitors (Strong): May increase the serum concentration of Sildenafil.