People can be re-infected with different strains of RSV from year to year, although subsequent infections tend to be less severe than the first/primary infection. Human respiratory syncytial virus (RSV) belongs to the recently defined Pneumoviridae family, Orthopneumovirus genus. We searched EMBASE and PubMed for diagnostic-accuracy studies of commercialized RSV RADTs. We performed a systematic review and meta-analysis to evaluate the accuracy of RADTs for diagnosis of RSV infection and to determine factors associated with accuracy estimates.
Mild RSV infections usually affect the upper respiratory tract (nose, throat). However, using RT-PCR in the clinical setting, it has been observed that this method may detect asymptomatic or very low levels of viral shedding, which could sometimes be of questionable significance (Among the 63 pediatric studies included in our subgroup analyses, approximately one-third declared industry sponsorship in the form of funding or in kind provision of study materials. Overall, we observed that these simple and rapid assays displayed consistently high specificity (97%) and positive likelihood ratio (25.5) results.
Our website services, content, and products are for informational purposes only. Studies that employed only viral culture or immunofluorescence as a comparator exhibited pooled sensitivities that were 9% or 14% higher, respectively, than those that used RT-PCR. However, your doctor may suspect RSV based on your medical history, time of year and a physical exam. Studies reporting sensitivity and specificity data compared to a reference standard (reverse transcriptase PCR [RT-PCR], immunofluorescence, or viral culture) were considered. Respiratory syncytial virus (RSV) testing is usually used during the RSV season to help diagnose the infection in people with moderate to severe symptoms and lower respiratory tract infection. Studies … Because of this disparity, further subgroup analyses were restricted to pediatric data (63 studies). Bronchiolitis is a common lower respiratory tract infection in infants and young children, and respiratory syncytial virus (RSV) is the most common cause of this infection. A medication called palivizimab (Synagis) is given to some high-risk children under 2 years old to help prevent serious RSV infections.RSV infection is rarely serious and can be treated successfully in various ways.© 2005-2020 Healthline Media a Red Ventures Company. Data that are not readily available to laboratory practitioners, such as clinical manifestations, presence of comorbidities, and duration of symptoms, are relevant because they could affect RADT accuracy. Although we were able to broadly stratify data into pediatric and adult age groups, we could not perform finer analyses on the effect of age, as further age subcategories were not uniformly reported, if at all. Similarly, RT-PCR and immunofluorescence were each considered as a whole, independently of the kit or protocol used. You can use over-the-counter fever reducers and pain relievers to manage your symptoms.
In determining the reference standard, traditional viral culture and shell vial culture were considered together, regardless of the cell line used. Respiratory syncytial virus (RSV) is an infection in your respiratory system (your airways). Because concurrent serious bacterial infection with RSV is uncommon, especially in children (There are currently four RSV diagnostic modalities in clinical use. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. RSV testing is used to detect respiratory syncytial virus, the most common cause of lower respiratory tract infections in infants around the world. But hospital care may be needed if severe symptoms occur.Your doctor may recommend an over-the-counter medication such as acetaminophen (Tylenol, others) to reduce fever. In August 2014, the Academy published the most recent guidelines to assist with identification of young children at increased risk of RSV hospitalization and most likely to benefit from prophylaxis.