We comply with the HONcode standard for trustworthy health information - (Dosage is titrated against tocolytic effect). -Initial dose: 10 mg orally 3 times a day-Maintenance dose: 10 to 30 mg orally 3 to 4 times a day-Maximum doe: 180 mg/day Extended-release tablets:-Initial dose: 30 to 60 mg orally once a day-Maintenance dose: 30 to 90 mg orally once a day-Maximum dose: Up to 120 mg/day Comments:-Doses may be increased gradually every 7 to 14 days. Plasma for determination of nifedipine and oxidized nifedipine concentrations Blood for DNA At that time, she will take a single dose of 10 mg immediate release nifedipine by mouth and blood samples will be collected for up to 6 hours. Applies to the following strengths: 10 mg; 20 mg; 30 mg; 60 mg; 90 mgSafety and efficacy have not been established in patients younger than 18 years.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Women who take part in the first phase will be asked to return 6-10 weeks after delivery.
At that time, she will take a single dose of 10 mg immediate release nifedipine by mouth and blood samples will be collected for up to 6 hours. The study will also look at the effects of genes (materials passed from parent to child that determine the make-up of the body) and other characteristics (for example mother's age, baby's age, race, and other diseases or drugs) on the ability of nifedipine to end the contractions. • Initial dose 20 mg orally stat. • If contractions persist after 30 minutes further 20 mg orally may be given at 30 min intervals for a further two doses. Secondary outcomes include time to uterine quiescence (≤6 contractions/hour), birth weight, gestational age at delivery, maternal and neonatal adverse effects. If contractions continue 60 minutes after the initial dose, nifedipine therapy should be considered a failure. The first will study women who are starting nifedipine for treatment of preterm labor. Blood samples will be obtained from the mother to determine the concentration of nifedipine and its metabolite, oxidized nifedipine, during one dosing interval.

Maximum initial dose: 40 mg in the first 40-60 minutes. Nifedipine tablets should be swallowed whole. Women who take part in the first phase will be asked to return 6-10 weeks after delivery.

Studies comparing nifedipine with ritodrine report fewer maternal side effects. This study will also examine the effect of pregnancy on how fast nifedipine is removed from the woman's body.This study will be conducted on two phases. We compared two dose regimens of tocolytic oral nifedipine. A different tocolytic agent may … After delivery, maternal and umbilical cord blood samples will be obtained, along with a piece of placenta. The purpose of this study is to identify the relationship between the amount of nifedipine in a woman's body and its effect on ending preterm (early) labor contractions and delaying delivery by at least 48 hours. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.This study looks at the effects of a mother's genes and other characteristics (mother's age, baby's age, race, and other diseases) on the ability of nifedipine to end contractions and prevent an early delivery. We will use this information to decide what amount of nifedipine women need to best treat preterm contractions. Blood pressure will also be monitored prior to collection of each blood sample A blood sample will also be obtained for DNA isolation to examine variants in genes involved in the nifedipine pathway.

Failure of the primary outcome occurs if, in the first 48 hours, patients deliver, rupture membranes, experience recurrent preterm labor, continue to contract or experience cervical change, or required the use of alternate tocolytics. NOTE: MAXIMAL DOSE IS 160 mg per day. Women with singleton pregnancies admitted in preterm labor (24 to 34 weeks) were randomized to high-dose (HD) nifedipine (N = 49; 20 mg loading dose, repeated in 30 minutes, daily 120 to 160 mg slow-release nifedipine for 48 hours followed …

Blood pressure will also be monitored prior to collection of each blood sample Nifedipine dose will be determined by the patient's physician. Available for Android and iOS devices. The maintenance dose is 20 mg PO q 8 hours for 24 hours, or longer, depending on prescription.

Maintenance dose Contractions should cease after the initial dose of 20-40 mg PO. It is not licensed for use as a tocolytic and there is no consensus on the optimal treatment dose or regimen. doses. Pregnant Women with preterm labor who have been prescribed immediate release nifedipine and admitted at Eskenazi Health Hospital or Indiana University Methodist Hospital. Nifedipine is a calcium antagonist that has the advantages of being orally administered and cheap.

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We will also collect data on uterine contractions and blood pressure through clinical monitoring. • Maintenance 20-40 mg orally qid for up to 48 hours.

This information will be used to decide what amount of nifedipine women need to best treat preterm contractions.Nifedipine 10 mg immediate release tablet by mouth loading dose Nifedipine administered orally every 15-20 minutes for the first hour to a maximum loading dose of 30 mg, followed by a maintenance dose of 10-20 mg immediate release nifedipine administered orally every 6 hoursNifedipine 10 mg immediate release tablet by mouth loading dose Nifedipine administered orally every 15-20 minutes for the first hour to a maximum loading dose of 30 mg, followed by a maintenance dose of 10-20 mg immediate release nifedipine administered orally every 6 hoursOther Name: Adalat, Nifediac, Nifedical, Procardia, Procardia XLThe primary study outcome is prevention of delivery for 48 hours with attainment of uterine quiescence, defined by 12 hours of six or fewer contractions per hour and no further cervical change.