Diuresis and saluresis usually begin within one hour and persist for 24 hours or longer. See Clinical studies of Metolazone tablets, USP, did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. 1; 5 mg - FD&C Blue No. Most of the drug is excreted in the unconverted form in the urine.Metolazone tablets, USP, are indicated for the treatment of salt and water retention including:Metolazone tablets, USP, are also indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class. Dosage adjustments of other antihypertensives may be necessary.The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with Metolazone therapy.Diuretic-induced hypokalemia can increase the sensitivity of the myocardium to digitalis. Supportive measures should be initiated as required to maintain hydration, electrolyte balance, respiration, and cardiovascular and renal function.Effective dosage of Metolazone tablets, USP, should be individualized according to indication and patient response. It is not known what effect the use of the drug during pregnancy has on the later growth, development, and functional maturation of the child. Worrisome? Drug interactions with metolazone oral and torsemide iv. The actions of Metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. In some instances depressed respiration may be observed. We compare the side effects and drug effectiveness of Torsemide and Metolazone. 40, D&C Red No. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.Metolazone tablets, USP, are usually well tolerated, and most reported adverse reactions have been mild and transient. No such effects have been reported with Metolazone.Based on clinical studies in which women received Metolazone in late pregnancy until the time of delivery, there is no evidence that the drug has any adverse effects on the normal course of labor or delivery.Metolazone appears in breast milk. A single daily dose is recommended. At high doses, lethargy of varying degree may progress to coma within a few hours. Carton of 100 tablets (10 tablets each blister pack x 10)Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [See USP Controlled Room Temperature].Protect from light. Temporary elevation of BUN has been reported, especially in patients with impairment of renal function. A dose titration is necessary if MYKROX Tablets are to be substituted for Metolazone tablets, USP, in the treatment of hypertension. When symptoms consistent with severe electrolyte imbalance appear rapidly, drug should be discontinued and supportive measures should be initiated immediately. put me on 200 mg torsemide that didnt work so they added metolazone on thurs...since then the ...today i m supposed to only take 100 mg torsemide and the metolazone. Adverse reactions are listed in decreasing order of severity within body systems.Chest pain/discomfort, orthostatic hypotension, excessive volume depletion, hemoconcentration, venous thrombosis, palpitations.Syncope, neuropathy, vertigo, paresthesias, psychotic depression, impotence, dizziness/lightheadedness, drowsiness, fatigue, weakness, restlessness (sometimes resulting in insomnia), headache.Toxic epidermal necrolysis (TEN), Stevens-Johnson Syndrome, necrotizing angiitis (cutaneous vasculitis), skin necrosis, purpura, petechiae, dermatitis (photosensitivity), urticaria, pruritus, skin rashes.Hepatitis, intrahepatic cholestatic jaundice, pancreatitis, vomiting, nausea, epigastric distress, diarrhea, constipation, anorexia, abdominal bloating, abdominal pain.Aplastic/hypoplastic anemia, agranulocytosis, leukopenia, thrombocytopenia.Hypokalemia, hyponatremia, hyperuricemia, hypochloremia, hypochloremic alkalosis, hyperglycemia, glycosuria, increase in serum urea nitrogen (BUN) or creatinine, hypophosphatemia, hypomagnesemia, hypercalcemia.Joint pain, acute gouty attacks, muscle cramps or spasm.In addition, adverse reactions reported with similar antihypertensive-diuretics, but which have not been reported to date for Metolazone tablets, USP, include: bitter taste, sialadenitis, xanthopsia, respiratory distress (including pneumonitis), and anaphylactic reactions. 2; 10 mg - D&C Yellow No. The daily dose depends on the severity of the patient's condition, sodium intake, and responsiveness.

See package circular for MYKROX Tablets.The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.