Code & Prescriber Medicinal Product Pack (Name, form & strength and pack size) Max qty packs Max qty units No. It is usually given at the same time as you receive your chemotherapy treatment and then 4 and 8 hours after your chemotherapy treatment.Drink at least 1 quart (4 cups; about 1 liter) of fluid daily while you are receiving mesna injection.Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.Mesna is also sometimes used to reduce the risk of hemorrhagic cystitis in people who receive the chemotherapy drug cyclophosphamide. Symptoms associated with “gasping syndrome” and other potential adverse reactions include gradual neurological deterioration, seizures, intracranial hemorrhage, hematological abnormalities, skin breakdown, hepatic and renal failure, hypotension, bradycardia, and cardiovascular collapse.
Mesna has a plasma clearance of 1.23 L/h/kg.No long-term studies in animals have been performed to evaluate the carcinogenic potential of Mesna.No studies on male or female fertility were conducted. Information is also available online at Keep all appointments with your doctor and the laboratory.Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving mesna injection.It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
The total daily dose of Mesna is 60% of the ifosfamide dose. MESNA. In healthy volunteers, Mesna was commonly associated with a rapid (within 24 hours) decrease in lymphocyte count, which was generally reversible within one week of administration.Because Mesna is used in combination with ifosfamide or ifosfamide-containing chemotherapy regimens, it is difficult to distinguish the adverse reactions which may be due to MESNEX from those caused by the concomitantly administered cytotoxic agents.Adverse reactions reasonably associated with Mesna administered intravenously and orally in four controlled studies in which patients received ifosfamide or ifosfamide-containing regimens are presented in .Table 3: Adverse Reactions in ≥ 5% of Patients Receiving Mesna in combinationThe following adverse reactions have been reported in the postmarketing experience of patients receiving Mesna in combination with ifosfamide or similar drugs, making it difficult to distinguish the adverse reactions which may be due to Mesna from those caused by the concomitantly administered cytotoxic agents. 5.4.3 Administration by continuous infusion Mesna is added to either: 3 litre bags of glucose 2.5%, sodium chloride 0.45% + potassium chloride 80mmol to run over 24 hours (via CADD prizm pump in backpack) or 4 x 1 litre bags of glucose 2.5%, sodium chloride 0.45% + potassium chloride 20mmol/L to run over 6 hours each. Standard Mesna Intravenous Regimen (number of patients)Advise the patient to take Mesna at the exact time and in the exact amount as prescribed. Mesna injection multidose vials also contain 10.4 mg/mL of benzyl alcohol as a preservative.
Revised: 12 2018The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Mesna is also sometimes used to reduce the risk of hemorrhagic cystitis in people who receive the chemotherapy drug cyclophosphamide.
Drink at least 1 quart (4 cups; about 1 liter) of fluid daily while you are receiving mesna injection. Talk with the doctor about the risks and side effects that may happen with ifosfamide. Do not give Mesna to other people, even if they have the same symptoms that you have.
The total daily dose of MESNEX is 60% of the ifosfamide dose. It works by protecting against some of the harmful effects of certain chemotherapy medications.Mesna comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility.