The pharmacokinetics of orally-administered didanosine were evaluated in 6 male and 6 female HIV seropositive patients to determine the effect of pretreatment with metoclopramide, an inducer of gastrointestinal motility, and loperamide, which retards motility. Die Bioverfügbarkeit nach oraler Einnahme liegt bei 60-80% bei einer Plasmahalbwertszeit von 4-5 Stunden. Pharmacokinetic parameter values were calculated using noncompartmental methods. Snapshot: A 19-year-old man travels to Southeast Asia for a backpacking trip. & Barbhaiya, R.H. Effect of metoclopramide and loperamide on the pharmacokinetics of didanosine in HIV seropositive asymptomatic male and female patients. Metoclopramide can cause tardive dyskinesia, a serious movement disorder that is often irreversible. Administration with loperamide affected the rate but not the extent of absorption. Clin Pharmacol Ther 50: 503–507Brunetto AL, Pearson ADJ, Gibson R, Bateman DN, Rashid MU, Laker MF (1990) The effect of pharmacological modification of gastric emptying and mouth-to-caecum transit time on the absorption of sugar probe marker molecules of intestinal permeability in normal man. Springer Br Med J 1: 587–589Shukla UA, Pittman KA, Barbhaiya RH (1992) Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers. 0.

Other drugs that have the same active ingredients (e.g.

You can also search for this author in generic drugs) are not considered. There is no known treatment for tardive dyskinesia. Der Wirkstoff Metoclopramid (MCP) wird zur Behandlung von Übelkeit und Brechreiz eingesetzt. 1 Definition. Eur J Clin Invest 20: 279–284Holgate AM, Read NW (1983) Relationship between small bowel transit time and absorption of a solid meal. 2017 Dec;26:132-137. doi: 10.1016/j.ebiom.2017.11.015. Other drugs that have the same active ingredients (e.g. Drug interactions are reported among people who take Metoclopramide hcl and Loperamide hydrochloride together. The patient was taking 10 to 40 mg 1 to 4 times weekly for about 4 months. generic drugs) are not considered. Drugs 15: 33–52Knupp CA, Stancato FA, Papp EA, Barbhaiya RH (1990) Quantitation of didanosine in human plasma and urine by high performance liquid chromatography. [2][21][22] This effect is thought to be caused by the drug's antidopaminergic effect. Serial blood and urine samples were collected for up to 12 h after each dose. No significant treatment or gender effects were observed for AUC or UR (urinary recovery). Clipboard, Search History, and several other advanced features are temporarily unavailable. Dig Dis Sci 28: 812–819McEvoy GK (1993) Metoclopramide.

Dekker, New YorkRiegelman S, Collier P (1980) The application of statistical moment theory to the evaluation of Winer BJ (1971) Statistical principles in experimental design, 2nd edn. Please enable it to take advantage of the complete set of features! Questions. 2 2. Springer The following warnings can help keep you safe. 1996 Mar;41(3):207-15. doi: 10.1111/j.1365-2125.1996.tb00184.x.Shyu WC, Knupp CA, Pittman KA, Dunkle L, Barbhaiya RH.Clin Pharmacol Ther. Loperamid akut ist ein Mittel gegen Durchfall. Name must be less than 100 characters & Barbhaiya, R.H. Effect of metoclopramide and loperamide on the pharmacokinetics of didanosine in HIV seropositive asymptomatic male and female patients. Drugs 15: 33–52Knupp CA, Stancato FA, Papp EA, Barbhaiya RH (1990) Quantitation of didanosine in human plasma and urine by high performance liquid chromatography. Clonidine and metoclopramide increased acetaminophen plasma levels (+115 and +152% at T15 min, P < 0.05 and P < 0.001, respectively), suggesting an accelerated GE. All rights reserved.

Br Med J 1: 587–589Shukla UA, Pittman KA, Barbhaiya RH (1992) Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers. J Chromatogr 533: 282–290Prescott P (1975) An approximate test for outliers in linear models. Metoclopramide increases serum prolactin in lactating and nonlactating women. You can also search for this author in Dig Dis Sci 28: 812–819McEvoy GK (1993) Metoclopramide. The pharmacokinetics of orally-administered didanosine were evaluated in 6 male and 6 female HIV seropositive patients to determine the effect of pretreatment with metoclopramide, an inducer of gastrointestinal motility, and loperamide, which retards motility.