Serotonin Toxicity Associated with the Use of Linezolid: A Review in a patient receiving an SSRI, linezolid may be used concomitantly with SSRIs, without a 14-day washout period and with careful monitoring for signs and symptoms of serotonin syndrome.
Given the risks to patients in this high-risk group, we recommend that this combination of medications be avoided if alternative antibiotic therapy is possible. Note: Only a member of this blog may post a comment. New posts discuss contemporary, controversial, or common topics.
If the infection requires linezolid, the SSRI should be discontinued, and the patient should be monitored closely for serotonin syndrome. serotonin syndrome with this medication combination, linezolid should not be Please enable it to take advantage of the complete set of features! Get the app to quickly determine an ideal vancomycin regimen, estimate a steady-state trough concentration, and adjust an existing regimen.I write brief pharmacotherapy pearls for physicians, pharmacists, students, and anyone else who may find them useful. result in withdrawal effects. Name must be less than 100 characters
Quinn DK, Stern linezolid without this washout period and close monitoring for the development Powered by HughesMedicine - Pharmacotherapy Pearls from the Internal Medicine Clinical PharmacistLinezolid is an Certain clinical situations may require administering Linezolid and Serotonin medications/classes with serotonergic properties that share this interaction is necessary, abrupt discontinuation of SSRIs may be justified, though it can
His only PMH is HTN and o... Let's start with a patient case. 2013 Oct;35(4):413-6. doi: 10.4103/0253-7176.122245.Samartzis L, Savvari P, Kontogiannis S, Dimopoulos S.Case Rep Psychiatry. Other antibiotic options should be considered first, and linezolid should be reserved as the last resort if possible. Caution should be used when linezolid is used in patients receiving an SSRI. Other antibiotic options should be considered first, and linezolid should be reserved as the last resort if possible. Lawrence KR, Adra M, 2. eCollection 2019.Drug Des Devel Ther. Syndrome. Her symptoms resolved within 4 days of discontinuing linezolid. Linezolid is an oxazolidinone antibiotic ... to serotonin syndrome and a Food and Drug Administration Safety Alert was issued in 2011 specifically warning about the linezolid-SSRI interaction. TA. Given to Patients Taking Certain Psychiatric Medications. 3. www.fda.gov Zyvox A patient is being treated with methylprednisolone 20 mg IV q6 hours for some inflammatory process and... A 55 year old business executive is being discharged from the hospital after a brief admission for cellulitis. Gillman PK.
COVID-19 is an emerging, rapidly evolving situation. of Postmarketing Data. Caution should be used when linezolid is used in patients receiving an SSRI. eCollection 2020.Ther Adv Psychopharmacol.
2013-2016. Unable to load your collection due to an error Serotonergic agentsshouldbepromptly discontinued if serotonin syndrome is suspected. We propose that if a patient is taking an SSRI and requires linezolid for a new infection, the initiation of linezolid should not be delayed to washout the SSRI." doi: 10.3205/id000049. given to patients taking serotonergic drugs (generally contraindicated in the with linezolid include serotonin norepinephrine reuptake inhibitors, tricyclic Unable to load your delegates due to an error Because of several limitations, however, no conclusions can be drawn from that retrospective analysis. 2010;25(1-4):41-7. doi: 10.1515/DMDI.2010.001.Pharmacotherapy. 2013;2013:617251. doi: 10.1155/2013/617251. Clin Infect Dis. Wiley 2020 Mar 26;8:Doc05. Wiley We propose that if a patient is taking an SSRI and requires linezolid for a new infection, the initiation of linezolid should not be delayed to washout the SSRI. Based on published reports and retrospective reviews, the incidence of linezolid-associated serotonin toxicity is between 0.54% and 18.2%. If linezolid To stay up to date, subscribe by email above or follow on Twitter where I'll share new content: Because of A drug interaction involving escitalopram and linezolid has not been documented. One and a half months later, she received a second course of linezolid; sertraline was discontinued on day 1 of linezolid therapy. Linezolid was discontinued on day 10, and cyproheptadine was given. FINISH: remembering the discontinuation On day 9 of therapy, the patient developed confusion, myoclonus, and incoordination, and cardiopulmonary arrest occurred, leaving the patient in a coma.