Our website services, content, and products are for informational purposes only. Many drugs have higher blood levels when taken with grapefruit or grapefruit juice, which can result in side effects. The effect does not last as long, but can lead to under-treatment of the thyroid condition.Levothyroxine tablets should be taken only with water and on an empty stomach first thing in the morning, and you should wait a full hour before eating or drinking anything else, said Dr. James Hennessey, director of clinical endocrinology at Beth Israel Deaconess Medical Center in Boston. Although antimicrobials are one of the most diverse categories of medications, there are only a few medications with known important grapefruit interactions: Erythromycin is used to treat several types of bacterial infections. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Yes.

If you’re curious about the grapefruit warning on many medicines, this article will help you understand why it’s there and what your options are. Nevertheless, a 2012 study showed that drinking 240 mL of grapefruit juice only had a minimal effect on its levels (Some narcotic pain relievers persist longer in the blood when taken with grapefruit.A few erectile dysfunction and prostate medications deserve attention regarding grapefruit interactions: Erectile dysfunction medications like sildenafil and tadalafil work by relaxing blood vessels, which increases blood flow to an erection.Because other blood vessels relax with these medications as well, increased blood levels of these drugs caused by grapefruit can decrease blood pressure (Moreover, prostate enlargement medications such as tamsulosin can also cause increased dizziness and low blood pressure when taken with grapefruit (Grapefruit should not be consumed with erectile dysfunction medications or certain prostate enlargement medications.While this article lists 31 common medications that interact with grapefruit, it’s not a complete list.

Regular consumption of foods that contain soy, walnuts or dietary fiber can also reduce the absorption of levothyroxine.If you’re concerned about whether you are achieving the right blood levels of a medication, check with your doctor to see if your dose needs adjustment. It is recommended that if you are taking lisinopril you should be advised to avoid moderately high or high potassium dietary intake.

The result can be kidney failure, fatal respiratory depression, gastrointestinal bleeding or a life-threatening heart arrhythmia, depending on the person and the drug.The effect of grapefruit on levothyroxine is the opposite: Drinking grapefruit juice — or orange juice — can inhibit uptake transporters and reduce the drug’s absorption. “Anything but water can potentially lead to malabsorption of levothyroxine,” he said.Supplements and other drugs can also interfere with absorption.

This may affect heart rhythm or function (Because antimicrobials are generally taken for a limited time, perhaps it’s easiest to simply avoid grapefruit while taking these medications. Some of them are affected by grapefruit, including: Clopidogrel depends on CYPs — the proteins that grapefruit limits — to work. Taking your medication a few hours apart from consuming it isn’t long enough. Therefore, the combination should be avoided. Grapefruit and a few of its close relatives, such as Seville oranges, tangelos, pomelos, and Minneolas, contain a class of chemicals called furanocoumarins.Furanocoumarins disrupt the normal function of CYPs. Although their blood levels are only slightly affected by small amounts of grapefruit, it may change the length of time they remain in the body (Colchicine is an older medication used to treat gout. It’s processed by CYPs and could interact with grapefruit. © 2005-2020 Healthline Media a Red Ventures Company. Here’s a closer look at 31 common drugs that may have dangerous interactions with grapefruit, as well as some alternatives. And some of these medications may have serious side effects when they interact with grapefruit. Your doctor usually can prescribe another medicine that doesn’t interact with grapefruit. However, several mood medications do interact with it, including: Drugs like quetiapine and lurasidone are used to treat mood and behavioral disorders. Ditto for a piece of fruit or a glass of milk. Healthline Media does not provide medical advice, diagnosis, or treatment. Simply taking your medication and grapefruit product at different times doesn't stop the interaction. If you are currently taking medications with grapefruit interactions, switch to an alternative drug or stop consuming grapefruit.If in doubt, reach out to your doctor or pharmacist for personalized advice.

One study compared some of these drugs in nine patients, some of whom consumed grapefruit. Eating grapefruit or drinking grapefruit juice can cause some medicines to enter your body faster.

A medication that's broken down too quickly won't have time to work. For example, he said, “if you take simvastatin and drink a single glass of grapefruit juice, it’s like taking three times the dose,” though the impact can be much more or much less, since individual susceptibilities vary widely.“Despite the concern for toxicity, which can be very serious in some cases, just exposure to grapefruit juice will not likely produce an adverse clinical reaction in most patients,” Dr. Bailey said.

On the other hand, a medication that stays in the body too long may build up to potentially dangerous levels.The list of medications that can interact with grapefruit includes commonly prescribed medications that:Another potential problem is that some foods and drinks may contain grapefruit but don't say so in the name or on the ingredients list. If the answer is yes, ask whether you need to eliminate that food from your diet.Mayo Clinic does not endorse companies or products.

Grapefruit is chock-full of vitamin C and other potent antioxidants and gives your immune system a boost, but grapefruit and grapefruit juice can be dangerous if you're taking a certain type of medication to control your blood pressure. This makes it more likely that you will have side effects from the medicine.