Contraindications. eCollection 2019 Oct 1.Clin Microbiol Rev. 2005 Sep;19(3):617-28. doi: 10.1016/j.idc.2005.05.005.Med Mal Infect. 2020 Aug 21;99(34):e21860. In addition, we provide a comprehensive assessment of the safety data associated with fluoroquinolone use in children. 2015 Jan;59(1):461-6. doi: 10.1128/AAC.04005-14. The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. doi: 10.1128/CMR.00007-19. Unable to load your collection due to an error 2019 Aug 14;32(4):e00007-19. Wiley Mary Anne Jackson, M.D., and colleagues from the American Academy of Pediatrics Committee on Infectious Diseases discuss the use of systemic and topical fluoroquinolones in children.The researchers note that fluoroquinolones are broad-spectrum agents which should be considered for use in specific situations. Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. The fluoroquinolones inhibit bacterial DNA gyrase and are bactericidal. 2003 Dec;22(12):1128-32. doi: 10.1097/01.inf.0000101994.25947.12.Medicine (Baltimore). However, damage to articular cartilage may not be as significant as was previously presumed. Although permanent or destructive arthropathy remains a significant concern, currently available data demonstrate that arthralgia and arthropathy are relatively uncommon in children and resolve following cessation of fluoroquinolone exposure without resulting in long-term sequelae. Free PMC article Unable to load your delegates due to an error None of the authors has any conflict of interest in regard to this manuscript. However, in adults, fluoroquinolones are the most commonly prescribed broad-spectrum antibiotics, resulting in the development of drug-resistant bacteria that can be challenging to treat effectively.