Talk to your doctor about other drug options that may work for you.© 2005-2020 Healthline Media a Red Ventures Company. Low blood cell counts have happened with this medicine (allopurinol tablets). Access to patient‐level data would have been particularly helpful for our subgroup analyses and to explain the heterogeneity among studies.
Unable to load your collection due to an error 2013 Oct;1(2):97-107. doi: 10.1159/000354108. This raises your risk of side effects.Your doctor may start you on a lowered dose or a different dosing schedule.
Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.. Allopurinol may also be used for purposes not listed in this medication guide. Allopurinol is used to prevent or lower high uric acid levels in the blood.
2006 May;4(3):319-33. doi: 10.1586/14779072.4.3.319.Cardiovasc Ther. Call your doctor if your gout symptoms get worse while you’re taking this drug.
While there was significant heterogeneity between trials, most of it could be explained by differences in the methodological quality of the trials. From the St Luke’s Roosevelt Hospital Center, Department of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY;Lahey Clinic Medical Center, Tufts University School of Medicine, Burlington, MAFrom the St Luke’s Roosevelt Hospital Center, Department of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY;From the St Luke’s Roosevelt Hospital Center, Department of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY;Lahey Clinic Medical Center, Tufts University School of Medicine, Burlington, MAFrom the St Luke’s Roosevelt Hospital Center, Department of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY;Use the link below to share a full-text version of this article with your friends and colleagues.
If you already have high blood pressure, consider using a different form of birth control. You should not need a new prescription for this medication to be refilled.
Disputes also exist in previous- ly conducted review and meta-analysis con-cerning the potential antihypertensive effect of allopurinol [18, 19].
Although a few of the studies included in the analysis were double‐blinded randomized controlled trials, other studies were of relatively poor quality, especially with regards to treatment allocation and concealment. All rights reserved.
Your doctor will adjust your dose as needed based on your serum uric acid level.150 mg per day.
Allopurinol reduces the production of uric acid in your body. A systematic review was conducted using Medline, PubMed, Embase, and the Cochrane Library for all the longitudinal studies that assessed the efficacy of allopurinol on systolic and diastolic BP. Your doctor may give you nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine to treat the flare-up and prevent more flares. You and your doctor should monitor certain health issues. WMD indicates weighted mean difference; CI, confidence interval. There were 5 studies of good quality (Jadad score ≥3) with low risk of bias and 7 studies of low quality (Jadad score <3) with high risk of bias.When all the studies were combined, irrespective of the study design, the mean baseline BP in these studies was 133.5±15.7/78.3±10 mm Hg. Authors of the papers were individually contacted in case the data were unclear.The main outcome of the present analysis was reduction of BP (systolic/diastolic) from baseline to follow‐up.The study quality was evaluated according to the Jadad composite score,An intention‐to‐treat traditional meta‐analysis was performed in accordance with the recommendations from the Cochrane Collaboration, the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Statement for randomized controlled trials, and Meta‐Analysis of Observational Studies in Epidemiology (MOOSE) statement for others. A total of 10 clinical studies with 738 participants were included in the analysis. CI indicates confidence interval.
Uric acid is another factor AFib and gout have in common.
This can help keep levels of this drug from building up too much in your body.Allopurinol oral tablet is used for long-term treatment.
All analyses were performed by We identified 10 clinical studies, with 10 control arms and 11 intervention arms, which fulfilled our inclusion criteria and were included in the final analysis ( Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) flow diagram of study selection.The overall characteristics of the included studies are listed in the Since we included both randomized and observational studies in our analyses, the included studies were of variable quality. Allopurinol oral tablet is a prescription drug that’s available as the brand-name drugs Allopurinol also comes in an intravenous (IV) form, which is only given by a healthcare provider.Allopurinol may be used as part of a combination therapy. doi: 10.1002/14651858.CD008652.pub3.Med Sci Monit. A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation).