If using a tuberculin syringe to measure a pediatric dose, do… The recommended maintenance dose of NEURONTIN in patients 5 to 11 years of age is 25 mg/kg/day to 35 mg/kg/day, given in three divided doses. Accordingly, ultimate dosage selection must be based upon clinical assessment of the patient.Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature] and protect from light.Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature] and protect from light.We comply with the HONcode standard for trustworthy health information - There were 31 infants, 33 children, and 24 adults studied; 19 digitalis-toxic patients were also investigated. Rather, the earliest and most frequent manifestation of excessive dosing with digoxin in infants and children is the appearance of cardiac arrhythmias, including sinus bradycardia. Do not stop using Neurontin suddenly, even if you feel fine.Gabapentin can cause life-threatening breathing problems, especially in older adults or people with Some people have thoughts about suicide or behavior changes while taking Neurontin. You can ask your healthcare provider or pharmacist for information about NEURONTIN that was written for healthcare professionals.For more information go to http://www.pfizer.com or call 1-800-438-1985.The 300-mg capsule shell also contains: yellow iron oxide.The 400-mg capsule shell also contains: red iron oxide, and yellow iron oxide.This Medication Guide has been approved by the U.S. Food and Drug Administration.You are encouraged to report negative side effects of prescription drugs to the FDA. Encourage women who are taking NEURONTIN during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling the toll free number 1-888-233-2334 or visiting There are no adequate data on the developmental risks associated with the use of NEURONTIN in pregnant women. Inhibition of the enzyme leads to an increase in the intracellular concentration of sodium and thus (by stimulation of sodium-calcium exchange) an increase in the intracellular concentration of calcium. Gabapentin, also known as neurontin or convalis, belongs to the class of organic compounds known as gamma amino acids and derivatives.

However, nausea and vomiting are not frequent in infants and small children.In addition to the undesirable effects seen with recommended doses, weight loss in older age groups and failure to thrive in infants, abdominal pain due to mesenteric artery ischemia, drowsiness, and behavioral disturbances including psychotic manifestations have been reported in overdose.In addition to cardiac monitoring, digoxin should be temporarily discontinued until the adverse reaction resolves and may be all that is required to treat the adverse reaction such as in asymptomatic bradycardia or digoxin-related heart block.
In nonclinical studies in mice, rats, and rabbits, gabapentin was developmentally toxic (increased fetal skeletal and In the U.S. general population, the estimated background risk of major birth defects and When pregnant mice received oral doses of gabapentin (500, 1000, or 3000 mg/kg/day) during the period of organogenesis, embryofetal toxicity (increased incidences of skeletal variations) was observed at the two highest doses. For more information, ask your healthcare provider or pharmacist.Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.

If more than 10 mg of digoxin was ingested by a child aged 1 to 3 years without heart disease, the outcome was uniformly fatal when Fab fragment treatment was not given. Patients with massive digitalis ingestion should receive large doses of activated charcoal to prevent absorption and bind digoxin in the gut during enteroenteric recirculation. These recommendations assume the presence of normal renal function.The loading dose should be administered in several portions, with roughly half the total given as the first dose. Evaluate patient carefully to determine the appropriate dose. The log of the partition coefficient (noctanol/ 0.05M phosphate buffer) at pH 7.4 is –1.25.Each Neurontin capsule contains 100 mg, 300 mg, or 400 mg of gabapentin and the following inactive ingredients: lactose, cornstarch, talc, gelatin, titanium dioxide, FD&C Blue No.

At 2000 mg/kg, the plasma gabapentin exposure (AUC) in rats is approximately 8 times that in humans at the MRHD.There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as NEURONTIN, during pregnancy. without secondary generalization, in adults and pediatric patients 3 years Serum digoxin levels in nontoxic patients obtained 6 to 24 hours after administration of a maintenance dose of digoxin were measured by means of a radioimmunoassay method.