Therefore, prochlorperazine is not recommended for use in pregnant patients except in cases of severe nausea and vomiting that are so serious and intractable that, in the judgment of the physician, drug intervention is required and potential benefits outweigh possible hazards.There have been reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines.Neonates exposed to antipsychotic drugs, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery.
Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see Cholestatic jaundice has occurred. Compazine is not recommended for children younger than age 2 or who are under 20 pounds. Prochlorperazine maleate is white or pale yellow, practically odorless, crystalline powder.
Potentiation of anticonvulsant effects does not occur.
(Or, injectable BenadrylSymptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. These adverse events include hypotension, anticholinergic effects (such as urinary retention, constipation, and confusion), and neuromuscular reactions (such as parkinsonism and tardive dyskinesia) (see Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. 606.10Prochlorperazine maleate is classified as an anti-emetic and antipsychotic agent.
Your list will be saved and can be edited at any time.The above information is provided for general It is practically insoluble in water and in alcohol; slightly soluble in warm chloroform.Each tablet, for oral administration contains prochlorperazine maleate equivalent to 5 mg or 10 mg of prochlorperazine. (Note: Levodopa has not been found effective in pseudo-parkinsonism.)
Dosage and frequency of administration should be adjusted according to the severity of the symptoms and the response of the patient. /viewarticle/912367 Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Begin with the lowest recommended dosage.Oral Dosage – Tablets: Usually one 5 mg or 10 mg tablet 3 or 4 times daily. Although response ordinarily is seen within a day or 2, longer treatment is usually required before maximal improvement is seen.Children seem more prone to develop extrapyramidal reactions, even on moderate doses. Controlled studies in pregnant women show no evidence of fetal risk.Antiemetic: Antidopaminergic effect, blocking dopamine receptors in the brain, blocking vagus nerve in GI tractAntipsychotic: Blocking mesolimbic dopamine receptors, and blocking alpha-adrenergic receptors (D1 and D2) in brainDuration: 3-4 hr (PO); 3-12hr (PR); extended-release, 10-12 hrAdditive: Amikacin, ascorbic acid injection, dexamethasone, dimenhydrinate, erythromycin, ethacrynate, lidocaine, nafcillin, penicillin G potassium (incompatible at higher concentrations), sodium bicarbonate, vitamins B and CSyringe (partial list): Atropine, chlorpromazine, cimetidine, diphenhydramine, fentanyl, glycopyrrolate, hydroxyzine, meperidine, metoclopramide, morphine sulfate (incompatible if phenol present)(? Uses for Compazine. ), chloramphenicol, chlorothiazide, floxacillin, furosemide, hydrocortisone, methohexital, penicillin G sodium, phenobarbital, thiopentalSyringe: Dimenhydrinate, hydromorphone(? Common side effects of Compazine include drowsiness, dizziness, missed menstrual periods (amenorrhea), blurred vision, skin reactions, and low blood pressure. Be sure the doctor knows ahead of time that you are taking this medication.Do not stop using Compazine® suddenly after long-term use, or you could have unpleasant withdrawal symptoms.