"Our results provide further evidence in support of the clinical evaluation of lipophilic statins as part of the treatment of ovarian cancer," Visvanathan said in a meeting news release. Recent observational studies raised the possibility that the use of statins may reduce overall mortality in various types of cancer. Speak to your doctor first if you have any concerns about your risk.”For media enquiries please contact the Cancer Research UK press office on +44 203 469 8300 or, out-of-hours, the duty press officer on +44 7050 264 059.Yarmolinsky J, et al, Association between genetically-proxied inhibition of HMG-CoA reductase and epithelial ovarian cancer, JAMA, 2020* More than 4 in 10 women with faults in BRCA1, and less than 2 in 10 women with BRCA2 faults, are estimated to develop ovarian cancer by age 80: Kuchenbaecker K, et al, Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers, JAMA, 2017** Based on the average annual number of new cases of ovarian cancer (ICD10 C56-57.4) diagnosed in the UK between 2015 and 2017. In this context, statin use has been correlated, variably, with a decrease in deaths from breast cancer… The use of lipophilic statins, specifically, were tied to a 43% risk of dying from ovarian cancer, the researchers found.The most significant reductions in death after using statins were among women with specific subtypes of ovarian cancer -- high-grade serous carcinoma (a 40% reduction) and endometrioid ovarian cancer (50% reduction).The results of the study were scheduled to be presented June 22 at an online meeting of the American Association for Cancer Research. Statins are cholesterol-lowering medications that are associated with a number of signaling pathways involved in carcinogenesis. Devreotes says his team plans further research on the effects of statins in people with cancer and compounds that block GGPP. However, it seems that most cells have a way to overcome the HMGCR inhibition with the help of the sterol … The associated reduction in ovarian cancer mortality is promising," said lead researcher Dr. Kala Visvanathan, a professor of epidemiology and oncology at Johns Hopkins Bloomberg School of Public Health in Baltimore.She pointed out that drugs to combat ovarian cancer are sorely needed, given its reputation as a "silent killer. It’s incredibly interesting that women whose bodies naturally inhibit the enzyme targeted by statins have a lower risk of ovarian cancer, but we don’t recommend anyone rushes to take statins specifically to reduce ovarian cancer risk because of this study.“It’s a promising result and I hope it sparks more research and trials into statins to demonstrate conclusively whether or not there’s a benefit.”Dr Rachel Orritt, Cancer Research UK’s health information manager, said: “This study is a great first step to finding out if statins could play a role in lowering ovarian cancer risk, and justifies future research into this area.“But there’s not yet enough evidence to know if statins themselves could reduce the risk of developing ovarian cancer safely.
Another line of thought is that statins lower circulating cholesterol, which helps regulate cell growth, though this research suggests that lower circulating cholesterol was not the method by which statins may reduce ovarian cancer risk.The findings suggest that long-term statin use could be associated with an estimated 40% reduction in ovarian cancer risk in the general population, although the estimate comes from looking at gene variation rather than statins themselves, and the exact mechanism by which these genes are associated with lower ovarian cancer risk is unclear.Ovarian cancer is the 6th most common cancer in women in the UK. And it’s important to remember that the risk of developing ovarian cancer depends on many things including age, genetics and environmental factors. A deadly attack in Pensacola, Florida, last year and another earlier this week in Somalia show the ongoing dangers of the terrorist group on which America set its sights 19 years ago. More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels. "That's because "there are no proven screening strategies" to catch ovarian tumors early, Visvanathan said, "so the disease is typically diagnosed at an advanced stage, when surgery is often not an option. They also looked at an additional 31,448 women who carried the BRCA1/2 fault, of whom 3,887 had ovarian cancer. Having the BRCA1/2 fault puts women at a higher risk of ovarian cancer than the general population*.While the study suggests that statins could lower ovarian cancer risk, more research needs to be done specifically looking at their use and impact on women’s risk of developing the disease.The researchers based at the University of Bristol looked at 63,347 women between the ages of 20 and 100 years old, of whom 22,406 had ovarian cancer. This is also the mechanism through which it is believed that statins kill cancer. Still, the results need to be confirmed in clinical trials and other populations before becoming part of standard practice, she said.Dr.