Consider referral to an ophthalmologist in patients who develop ocular symptoms or use fluticasone propionate nasal spray long-termGeneral Disorders and Administration Site ConditionsAdvise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use).Before using fluticasone propionate nasal spray, tell your healthcare provider about all of your medical conditions, including if you:Tell your healthcare provider about all the medicines you take,Especially, tell your healthcare provider if you take antifungal or anti-HIV medicines.How should I use fluticasone propionate nasal spray?Read the step-by-step instructions for using fluticasone propionate nasal spray at the end of this Patient Information.What are the possible side effects of fluticasone propionate nasal spray?Fluticasone propionate nasal spray may cause serious side effects, including:a certain fungal infection in your nose, mouth, or throat (thrush).hole in the cartilage of your nose (nasal septal perforation).weakened immune system and increased chance of getting infections (immunosuppression).lowered steroid hormone levels (adrenal insufficiency).The most common side effects of fluticasone propionate nasal spray include:Keep fluticasone propionate nasal spray and all medicines out of the reach of children.General information about the safe and effective use of fluticasone propionate nasal spray.What are the ingredients in fluticasone propionate nasal spray USP?Fluticasone propionate nasal spray is for use in your nose only.Read this information before you start using your fluticasone propionate nasal spray.Your fluticasone propionate nasal spray must be primed before you use it for the first time and when you have not used it for a week or more.How to prime your fluticasone propionate nasal spray:Do not try to unblock the nasal applicator by inserting a pin or other sharp object.We comply with the HONcode standard for trustworthy health information - In animals, teratogenicity characteristic of corticosteroids, decreased fetal body weight and/or skeletal variations, were observed in rats, mice, and rabbits with subcutaneously administered maternal toxic doses of fluticasone propionate 5 times, equivalent to, and less than the maximum recommended human daily intranasal dose (MRHDID) on a mcg/mThe estimated risk of major birth defects and miscarriage for the indicated population is unknown.

Do not take extra doses or stop taking fluticasone propionate nasal spray without talking to your healthcare provider.1. Thus, no statistically significant effect on growth was noted compared with placebo. Like oral antihistamines, nasal antihistamine sprays manage symptoms by blocking the release of the chemical histamine, which is important in allergic reactions. Nasal antihistamines and decongestants are products that contain either an antihistamine or a decongestant, in a device suitable for nasal use.Antihistamines block the action of histamine which is released by cells in response to allergens. Due to the low bioavailability by the intranasal route, the majority of the pharmacokinetic data was obtained via other routes of administration.The percentage of fluticasone propionate bound to human plasma proteins averaged 99%.

One study compared a fluticasone furoate nasal steroid spray with taking a combination of the oral antihistamine (cetirizine) and antileukotriene (montelukast).

Use of intranasal and inhaled corticosteroids may result in the development of glaucoma and/or cataracts. Nasal sprays with corticosteroids block a variety of allergic substances. An OTC allergy spray that’s formulated with corticosteroids—a type of medicine approved by the FDA to treat nasal allergy symptoms—provides more complete relief† of total nasal symptoms than an antihistamine. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for fluticasone propionate nasal spray and any potential adverse effects on the breastfed child from fluticasone propionate nasal spray or from the underlying maternal condition.The safety and effectiveness of fluticasone propionate nasal spray in children aged 4 years and older have been established [A 1-year placebo-controlled trial was conducted in 150 pediatric subjects (aged 3 to 9 years) to assess the effect of fluticasone propionate nasal spray (single daily dose of 200 mcg) on growth velocity. The same total daily dose, 1 spray in each nostril administered twice daily (e.g., 8 a.m. and 8 p.m.) is also effective. Steroid Nasal Sprays. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. If over-the-counter treatments aren’t effective for your nasal allergies, see a doctor to find out about prescription treatments. Preliminary results from the new in vitro study indicated that chlorpheniramine maleate—an over-the-counter anti-inflammatory drug typically used to relieve allergy, cold or flu symptoms, like runny nose, sneezing, itchy and watery eyes—could reduce the presence of infection when combined with a nasal spray solution. Steroid nasal sprays, also called corticosteroid nasal sprays, are anti-inflammatory medicines that you spray into your nose.