Follow all directions on your prescription label and read all medication guides or instruction sheets. Other drugs may interact with allopurinol, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use allopurinol only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. Lerman S, Megaw JM, Gardner K. Long-term ingestion of allopurinol, an antihyperuricemic agent used to treat gout, may be related to the development of lens opacities in relatively young patients (second to fifth decades of life). The research data obtained by studying human neurodegenerative diseases is also applicable in aging dogs. The usual initial starting dose to treat Cushing's disease in dogs is 0.45 mg/pound given once a day in the morning. This can cause your body to process drugs more slowly. Allopurinol during breastfeeding is not recommended. If the rash recurs, Allopurinol should be permanently withdrawn as more severe hypersensitivity may occur (see section 4.8 7 Angioedema has been reported to occur with and without signs and symptoms of a more generalised hypersensitivity reaction.8 Fever has been reported to occur with and without signs and symptoms of a more generalised Allopurinol hypersensitivity reaction (see section 4.8 9 The occurrence of increased thyroid stimulating hormone (TSH) in the relevant studies did not report any impact on free T4 levels or had TSH levels indicative of subclinical hypothyroidism.Reporting suspected adverse reactions after authorisation of the medicinal product is important. Extra caution should be exercised if renal function is poor (300 to 600 mg daily in moderately severe conditions,If dosage on a mg/kg bodyweight basis is required, 2 to 10 mg/kg bodyweight/day should be used. Particular attention should be paid to advice in section 4.2 Since allopurinol and its metabolites are excreted by the kidney, impaired renal function may lead to retention of the drug and/or its metabolites with consequent prolongation of plasma half-lives. After recovery from mild reactions, Allopurinol may, if desired, be re-introduced at a small dose (e.g. Allopurinol can lower blood cells that help your body fight infections. Am J Ophthalmol. SJS/TEN can still occur in patients who are found to be negative for HLA-B*5801 irrespective of their ethnic origin.Patients with chronic renal impairment and concomitant diuretic use, in particular thiazides, may be at increased risk of developing hypersensitivity reactions including SJS/TEN associated with allopurinol. Common side effects when used by mouth include itchiness and rash. If facilities are available to monitor plasma oxipurinol concentrations, the dose should be adjusted to maintain plasma oxipurinol levels below 100 micromol/litre (15.2 mg/litre). Estimates of bioavailability vary from 67% to 90%. Adverse drug reactions identified through post-marketing surveillance were considered to be rare or very rare.
If considered necessary haemodialysis may be used.Pharmacotherapeutic group: Antigout preparations inhibiting uric acid productionAllopurinol is a xanthine-oxidase inhibitor. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme; website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.Ingestion of up to 22.5 g allopurinol without adverse effect has been reported. Measured serum allopurinol and oxipurinol concentrations in clinical practice showed large variability with a range of <0.5-4.3 mg/L for allopurinol and <1.0-39.2 mg/L for oxipurinol, respectively. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.Allopurinol can cause a severe allergic reaction. There is inadequate evidence of safety of Allopurinol in human pregnancy, although it has been in wide use for many years without apparent ill consequence (see section 5.3). Rechallenge should not be undertaken in patients with hypersensitivity syndrome and SJS/TEN. The incidence is higher in the presence of renal and/or hepatic disorder.Hepatitis (including hepatic necrosis and granulomatous hepatitis) Stevens-Johnson syndrome/toxic epidermal necrolysis General disorders and administration site conditions1 Very rare reports have been received of thrombocytopenia, agranulocytosis and aplastic anaemia, particularly in individuals with impaired renal and/or hepatic function, reinforcing the need for particular care in this group of patients.2 A delayed multi-organ hypersensitivity disorder (known as hypersensitivity syndrome or DRESS) with fever, rashes, vasculitis,lymphadenopathy, pseudo lymphoma, arthralgia, leucopenia, eosinophilia hepato-splenomegaly, abnormal liver function tests, and vanishing bile duct syndrome (destruction and disappearance of the intrahepatic bile ducts) occurring in various combinations.
This information is intended for use by health professionalsExcipient with known effect: Each tablet contains 130.66 mg of lactose monohydrateWhite, circular, biconvex, uncoated tablets impressed “C” and the identifying letters “AD” on either side of a central division line on one face.Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. Serious side effects and their symptoms can include the following:Allopurinol oral tablet can interact with other medications, vitamins, or herbs you may be taking. These reactions are clinical diagnoses, and their clinical presentations remain the basis for decision making. Name must be less than 100 characters Our website services, content, and products are for informational purposes only. Use in pregnancy only when there is no safer alternative and when the disease itself carries risks for the mother or unborn child. Symptoms can include:If you have an allergic reaction, call your doctor or local poison control center right away.