Important Information You should not take this medication if you are allergic to tolterodine or fesoterodine ( Toviaz ), if you have untreated or uncontrolled narrow-angle glaucoma , or if you have a blockage of the urinary tract, stomach, or intestines. • Convulsions or pronounced excitation: treat with benzodiazepines 2010 Jan;105(1):58-66. doi: 10.1111/j.1464-410X.2009.09086.x.Ginsberg D, Schneider T, Kelleher C, Van Kerrebroeck P, Swift S, Creanga D, Martire DL.BJU Int. The clinical relevance of the increased exposure of these metabolites is unknown. Therefore an increase of plasma levels of drugs metabolised by these isoenzymes is not expected when dosed in combination with tolterodine.There are no adequate data from the use of tolterodine in pregnant women. Wiley Because of the differences in the protein-binding characteristics of tolterodine and the 5-hydroxymethyl metabolite, the exposure (AUC) of unbound tolterodine in poor metabolisers is similar to the combined exposure of unbound tolterodine and the 5-hydroxymethyl metabolite in patients with CYP2D6 activity given the same dosage regimen. ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdosage (see section 4.4). Efficacy of Tolterodine Tartrate has not been demonstrated in children (see section 5.1). Tolterodine is a benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. (see section 5.1)Reporting suspected adverse reactions after authorisation of the medicinal product is important. In addition, the fesoterodine and tolterodine ER groups showed significantly greater improvements in HRQoL than the placebo group, with positive changes in most domains of the KHQ and an improvement in ICIQ-SF … erythromycin and clarithromycin), antifungal agents (e.g. It is used to treat disorders of the urinary bladder that affect urination. In poor metabolisers the reduced clearance leads to significantly higher serum concentrations of tolterodine (about 7-fold) and negligible concentrations of the 5-hydroxymethyl metabolite are observed. The reduction in wetting episodes at 1 year was> 90% in 23 (68%), more than half in five and less than half (or failure) in six patients. Tolterodine should be used with caution in patients with risk factors for QT-prolongation including: - Congenital or documented acquired QT prolongation - Electrolyte disturbances such as hypokalaemia, hypomagnesaemia and hypocalcaemia - Relevant pre-existing cardiac diseases (i.e. The potential risk for humans is unknown. COVID-19 is an emerging, rapidly evolving situation. • Urinary retention: treat with catheterization
The primary metabolic route is mediated by the polymorphic enzyme CYP2D6 and leads to the formation of the 5-hydroxymethyl metabolite. 000094544_PB. 2013 Aug;112(3):373-85. doi: 10.1111/bju.12174.DuBeau CE, Morrow JD, Kraus SR, Creanga D, Bavendam T.Neurourol Urodyn. Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. doi: 10.1111/j.1464-410X.2008.07907.x. • Respiratory insufficiency: treat with artificial respiration Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Do not take extra medicine to make up the missed dose. The clinical relevance of these findings is unknown.Tolterodine Tartrate 2mg film-coated tablets are packed in transparent PVC/PE/PVDC/Aluminium blisters. 2010 Oct;71(5):273-88. doi: 10.1016/j.curtheres.2010.10.003. Other side effects include: constipation, dyspepsia, and dizziness.