Store in the original package to protect from light and moisture.Sinemet 12.5 mg/50 mg Tablets: PVC/AL blister packs of 30 or 90 tablets.Sinemet 10mg/100mg: AL/AL blister packs of 100 tablets.Sinemet Plus 25 mg/100 mg, Sinemet 25mg/250mg: PVC/AL blister packs of 100 tablets.© Merck Sharp & Dohme Limited 2019. The dose should be increased by 1 mg every 3 to 5 days three times daily until benefit or side effects.
This dosage schedule provides 75 mg of carbidopa per day.
Patients with a history of convulsions should be treated with caution.As with levodopa, periodic evaluation of hepatic, haematopoetic, cardiovascular and renal function are recommended during extended therapy.Patients with chronic wide-angle glaucoma may be treated cautiously with 'Sinemet', provided the intra-ocular pressure is well controlled and the patient monitored carefully for changes in intra-ocular pressure during therapy.If general anaesthesia is required, therapy with 'Sinemet' may be continued for as long as the patient is permitted to take fluids and medication by mouth. Experience with total daily dosages of carbidopa greater than 200 mg is limited. Sinemet Dosage for Parkinson's Disease There is no standard Sinemet dosage that will work for all people. 'Sinemet' may be administered concomitantly with the manufacturer's recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g.
Review of treatment is recommended if such symptoms develop.Caution should be exercised when the following drugs are administered concomitantly with 'Sinemet'.Postural hypotension can occur when 'Sinemet' is added to the treatment of patients already receiving antihypertensive drugs. Following an oral dose approximately 50% is recorded in the urine, with about 3% of this as unchanged drug. Follow your doctor's orders or the directions on the label.
Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets of SINEMET 25-100 a day is reached.If SINEMET 10-100 is used, dosage may be initiated with one tablet three or four times a day.
)'Sinemet 12.5 mg/50 mg Tablets' contain quinoline yellow (E104), maize starch, pregelatinised maize starch, microcrystalline cellulose, magnesium stearate.
Initial dosage should not be given at intervals of less than 6 hours. The tablet can be divided into equal doses. The usual duration of treatment is five to ten days depending on the indication and clinical response. Furthermore a reduction of dosage or termination of therapy may be considered.All patients should be monitored carefully for the development of mental changes, depression with suicidal tendencies, and other serious antisocial behaviour. When more levodopa is required, SINEMET 25-250 should be substituted for SINEMET 25-100 or SINEMET 10-100. A lower dose of levodopa can be used, reducing the incidence and severity of side effects. Patients must be informed of this and advised to exercise caution while driving or operating machines during treatment with levodopa.
0 The dosing interval between doses should be prolonged by 30 to 50% at intervals ranging from 4 to 12 hours.
'Sinemet 10 mg/100 mg Tablets' and 'Sinemet 25 mg/250 mg Tablets' contain Indigotine (E-132), pregelatinised starch, corn starch, microcrystalline cellulose, magnesium stearate.Sinemet Plus 25 mg/100 mg, Sinemet 10 mg/100 mg and Sinemet 25 mg/250 mg: 24 months Sinemet 12.5 mg/50 mg: Do not store above 25°C. Patients not receiving levodopa: In patients with mild to moderate disease, the initial recommended dose is 1 tablet of SINEMET CR 50-200 b.i.d.