Medscape - Indication-specific dosing for Combivent Respimat (albuterol, ipratropium), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & … Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. (COPD) were evaluated for the bronchodilator efficacy of COMBIVENT Inhalation
no evidence of impaired fertility.There are no adequate and well-controlled studies of Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol,
Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol contains a microcrystalline suspension of ipratropium bromide and albuterol sulfate in a pressurized metered-dose … or related food products such as soybean and peanut. Never throw the
Children—Use and dose must be determined by your doctor.
adults on a mg/m² basis) revealed no evidence of tumorigenicity.
as seen in Table 1.Additional adverse reactions,
bromide (as the monohydrate) and albuterol sulfate.Ipratropium bromide is an anticholinergic bronchodilator
Call your doctor if you experience any of these symptoms.
Controlled studies in pregnant women show no evidence of fetal risk.Ipratropium: Anticholinergic (parasympatholytic) agent; inhibits vagally mediated reflexes by antagonizing acetylcholine action; prevents increase in intracellular calcium concentration caused by interaction of acetylcholine with muscarinic receptors on bronchial smooth musclePeak plasma time: Albuterol, 3 hr (from portion swallowed)Peak plasma concentration: Albuterol, 419-802 pg/mL (from portion swallowed)Albuterol: Conjugatively metabolized to albuterol 4'-O-sulfateIpratropium: Partially metabolized to inactive ester hydrolysis productsHalf-life: Albuterol, 3.6 hr (after 30-min infusion of 1.5 mg); ipratropium, 2 hr (after inhalation or IV administration)Excretion: Albuterol, urine (27%); ipratropium, urine (4%)See individual package inserts for instructions on useAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. the action of albuterol on the Patients should be cautioned to avoid spraying the aerosol
for the first time and in cases where the aerosol has not been used for more
was observed as increased Albuterol has been shown to be teratogenic in mice and
comparable group of 16 healthy male volunteers; the mean terminal half-life
agents due to the increased risk of adverse cardiovascular effects.
ipratropium bromide and 120 mcg of albuterol sulfate from the valve and
(equivalent to 90 mcg albuterol base) from the mouthpiece. MAXALT-MLT prescription and dosage sizes information for physicians and healthcare professionals. more frequently than usual, medical attention should be sought immediately. 2001
mesovarium in a 2-year study in the rat at dietary doses of 2, 10, and 50 mg/kg
following a 30-minute infusion of 1.5 mg was 3.9 hours with a mean clearance of
of effect as measured by FEV1 was 4 to 5 hours for COMBIVENT Inhalation Aerosol
doses of ipratropium or albuterol in addition to the recommended doses of
mg/kg (approximately 1900 times the maximum recommended daily inhalation dose
(approximately 1600 times the maximum recommended daily inhalation dose in
Ipratropium bromide is not readily absorbed into the systemic circulation after inhalation either from the surface of the lung or from the gastrointestinal tract as confirmed by blood level and renal excretion studies. The relevance of these findings to humans
the co-administration of propranolol. (0.025, 0.25, and 2.5 mg/kg) showed It is not known whether the components of COMBIVENT
Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol have
uptake processes for catecholamines nor for In a pharmacokinetic study in 12 healthy male volunteers of
The total number of inhalations should not exceed 6 in 24 hours1 Safety and efficacy of additional doses of COMBIVENT RESPIMAT beyond 6 inhalations/24 hours have not been studied.
ipratropium bromide-containing products (singly or in combination with
Inhalation Aerosol contributed to the improvement in pulmonary function
have demonstrated the occurrence of cardiac arrhythmias and sudden death (with
dichlorotetrafluoroethane (CFC-114), substances which harm the The contents of Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol are under
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
The median time to onset of
patients being treated with monoamine oxidase inhibitors or tricyclic
trichloromonofluoromethane as propellants and soya lecithin.COMBIVENT Inhalation Aerosol is indicated for use in patients with The dose of COMBIVENT® Inhalation Aerosol is two inhalations
576.7 . Following this single
treatment with COMBIVENT Inhalation Aerosol becomes less effective for
Your list will be saved and can be edited at any time.The above information is provided for general
Exposure to temperatures above 120°F may cause bursting. studied in patients with hepatic or renal insufficiency or in the elderly (see No specific pharmacokinetic studies were conducted to evaluate potential drug-drug interactions.The bronchodilation following inhalation of ipratropium