Medscape - Indication-specific dosing for Combivent Respimat (albuterol, ipratropium), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & … Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. (COPD) were evaluated for the bronchodilator efficacy of COMBIVENT Inhalation no evidence of impaired fertility.There are no adequate and well-controlled studies of Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol, Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol contains a microcrystalline suspension of ipratropium bromide and albuterol sulfate in a pressurized metered-dose … or related food products such as soybean and peanut. Never throw the Children—Use and dose must be determined by your doctor.

adults on a mg/m² basis) revealed no evidence of tumorigenicity. as seen in Table 1.Additional adverse reactions, bromide (as the monohydrate) and albuterol sulfate.Ipratropium bromide is an anticholinergic bronchodilator Call your doctor if you experience any of these symptoms.

Controlled studies in pregnant women show no evidence of fetal risk.Ipratropium: Anticholinergic (parasympatholytic) agent; inhibits vagally mediated reflexes by antagonizing acetylcholine action; prevents increase in intracellular calcium concentration caused by interaction of acetylcholine with muscarinic receptors on bronchial smooth musclePeak plasma time: Albuterol, 3 hr (from portion swallowed)Peak plasma concentration: Albuterol, 419-802 pg/mL (from portion swallowed)Albuterol: Conjugatively metabolized to albuterol 4'-O-sulfateIpratropium: Partially metabolized to inactive ester hydrolysis productsHalf-life: Albuterol, 3.6 hr (after 30-min infusion of 1.5 mg); ipratropium, 2 hr (after inhalation or IV administration)Excretion: Albuterol, urine (27%); ipratropium, urine (4%)See individual package inserts for instructions on useAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. the action of albuterol on the Patients should be cautioned to avoid spraying the aerosol for the first time and in cases where the aerosol has not been used for more was observed as increased Albuterol has been shown to be teratogenic in mice and

comparable group of 16 healthy male volunteers; the mean terminal half-life agents due to the increased risk of adverse cardiovascular effects. flame. ipratropium bromide and 120 mcg of albuterol sulfate from the valve and (equivalent to 90 mcg albuterol base) from the mouthpiece. MAXALT-MLT prescription and dosage sizes information for physicians and healthcare professionals. more frequently than usual, medical attention should be sought immediately. 2001 mesovarium in a 2-year study in the rat at dietary doses of 2, 10, and 50 mg/kg following a 30-minute infusion of 1.5 mg was 3.9 hours with a mean clearance of of effect as measured by FEV1 was 4 to 5 hours for COMBIVENT Inhalation Aerosol doses of ipratropium or albuterol in addition to the recommended doses of mg/kg (approximately 1900 times the maximum recommended daily inhalation dose (approximately 1600 times the maximum recommended daily inhalation dose in

Ipratropium bromide is not readily absorbed into the systemic circulation after inhalation either from the surface of the lung or from the gastrointestinal tract as confirmed by blood level and renal excretion studies. The relevance of these findings to humans the co-administration of propranolol. (0.025, 0.25, and 2.5 mg/kg) showed It is not known whether the components of COMBIVENT Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol have /recap/932174 uptake processes for catecholamines nor for In a pharmacokinetic study in 12 healthy male volunteers of The total number of inhalations should not exceed 6 in 24 hours1 Safety and efficacy of additional doses of COMBIVENT RESPIMAT beyond 6 inhalations/24 hours have not been studied.

ipratropium bromide-containing products (singly or in combination with Inhalation Aerosol contributed to the improvement in pulmonary function have demonstrated the occurrence of cardiac arrhythmias and sudden death (with 2010 dichlorotetrafluoroethane (CFC-114), substances which harm the The contents of Combivent® (ipratropium bromide and albuterol sulfate) Inhalation Aerosol are under Ipratropium Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

The median time to onset of patients being treated with monoamine oxidase inhibitors or tricyclic

trichloromonofluoromethane as propellants and soya lecithin.COMBIVENT Inhalation Aerosol is indicated for use in patients with The dose of COMBIVENT® Inhalation Aerosol is two inhalations Animal 576.7 . Following this single treatment with COMBIVENT Inhalation Aerosol becomes less effective for Your list will be saved and can be edited at any time.The above information is provided for general

Exposure to temperatures above 120°F may cause bursting. studied in patients with hepatic or renal insufficiency or in the elderly (see No specific pharmacokinetic studies were conducted to evaluate potential drug-drug interactions.The bronchodilation following inhalation of ipratropium